Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives

被引：15
作者：
Kheder, Nabila Abdelshafy [1 ,2 ]
机构：
[1] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt
[2] King Khalid Univ, Dept Pharmaceut Chem, Fac Pharm, Abha, Saudi Arabia
来源：
MOLECULES | 2016年 / 21卷 / 03期
关键词：
bis-pyrrole; antibacterial activity; antifungal activity; hydrazonoyl halides; molecular docking; ANTIMICROBIAL EVALUATION; CONVENIENT SYNTHESIS; THIOPHENE; THIAZOLE; PYRAZOLE; FACILE; 1,3,4-THIADIAZOLE; PYRIDINE;
D O I：
10.3390/molecules21030326
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A convenient synthesis of some novel bis-pyrrole derivatives via hydrazonoyl halides is described. Antimicrobial evaluation of some selected examples of the synthesized products was carried out. The bis-pyrrole derivative having chloro substituents showed good activity against all of the used microbes. The molecular docking of the bis-pyrrole derivatives was performed by the Molecular Operating Environment (MOE) program.
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页数：9
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