An efficient one-pot reaction of indoles, nitroacetate, and paraformaldehyde for the synthesis of tryptophan derivatives

被引：20
作者：
Sui, Yong
Liu, Li [1 ]
Zhao, Jun-Ling
Wang, Dong
Chen, Yong-Jun
机构：
[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Biol Chem Lab, Beijing 100080, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 22期
基金：
中国国家自然科学基金;
关键词：
tryptophan; one-pot; indole; nitroacetate;
D O I：
10.1016/j.tetlet.2007.04.002
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the synthesis of tryptophan analogues has been developed via one-pot reaction of commercial available indoles, ethyl nitroacetate, and paraformaldehyde in the presence of molecular sieves. The reaction provided tryptophan nitro-precursors in moderate to good yields, which were further converted to alpha-hydroxymethylated tryptophan derivatives catalyzed by DABCO in high yields. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3779 / 3782
页数：4
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