Hemoglobin-based blood substitutes and the hazards of blood radicals

被引：37

作者：

Alayash, AI ^{[1
]}

机构：

[1] US FDA, Ctr Biol Evaluat & Res, Lab Plasma Derivat, Bethesda, MD 20892 USA

来源：

FREE RADICAL RESEARCH | 2000年 / 33卷 / 04期

关键词：

hemoglobin; blood substitutes; free radicals;

D O I：

10.1080/10715760000300881

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell-free hemoglobins, chemically altered or genetically expressed in microbial host systems, have been developed as oxygen-carrying therapeutics. Site-directed modifications are introduced and serve to stabilize the protein molecules in a tetrameric and/or a polymeric functional form. Animal studies, as well as recent clinical studies, have suggested these proteins probably deliver oxygen to tissues. However, concerns still persist regarding the interference of hemoglobin and its oxidation products with the vascular redox balance, potentially impeding its clinical usefulness. This article reviews our current understanding of heme-mediated toxicities and some of the emerging protective strategies used to overcome hemoglobin side reactions.

引用

页码：341 / 348

页数：8