Avian influenza A virus (H7N7) epidemic in the Netherlands in 2003: Course of the epidemic and effectiveness of control measures

被引：221
|
作者：
Stegeman, A
Bouma, A
Elbers, ARW
de Jong, MCM
Nodelijk, G
de Klerk, F
Koch, G
van Boven, M
机构：
[1] Univ Utrecht, Fac Vet Med, Dept Farm Anim Hlth, Utrecht, Netherlands
[2] Univ Wageningen & Res Ctr, Dept Virol, Cent Inst Anim Dis Control, Lelystad, Netherlands
[3] Univ Wageningen & Res Ctr, Div Infect Dis, Anim Sci Grp, Lelystad, Netherlands
[4] Minist Agr Nat & Food Qual, Food & Cnsumer Prod Safety Author, Natl Inspect Serv Livestock & Meat, The Hague, Netherlands
来源：
JOURNAL OF INFECTIOUS DISEASES | 2004年 / 190卷 / 12期
关键词：
D O I：
10.1086/425583
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
An epidemic of high-pathogenicity avian influenza ( HPAI) A virus subtype H7N7 occurred in The Netherlands in 2003 that affected 255 flocks and led to the culling of 30 million birds. To evaluate the effectiveness of the control measures, we quantified between-flock transmission characteristics of the virus in 2 affected areas, using the reproduction ratio R-h. The control measures markedly reduced the transmission of HPAI virus: R-h before detection of the outbreak in the first infected flock was 6.5 (95% confidence interval [CI], 3.1 - 9.9) in one area and 3.1 in another area, and it decreased to 1.2 ( 95% CI, 0.6 - 1.9) after detection of the first outbreak in both areas. The observation that R-h remained 11 suggests that the containment of the epidemic was probably due to the reduction in the number of susceptible flocks by complete depopulation of the infected areas rather than to the reduction of the transmission by the other control measures.
引用
收藏
页码：2088 / 2095
页数：8
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