A Facile Access to Some New Pyrazole, 1,3,4-Thiadiazole, and Thiophene Derivatives via -Ketosulfones

被引：13

作者：

Dawood, Kamal M. ^{[1
]}

Kheder, Nabila A. ^{[1
]}

Ragab, Eman A. ^{[1
]}

Mohamed, Sanaa N. ^{[1
]}

机构：

[1] Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2010年 / 185卷 / 02期

关键词：

Hydrazonoyl halides; ketosulfones; pyrazoles; pyridines; 1; 3; 4-thiadiazoles; thiophenes; BETA-KETOSULFONES; HETEROCYCLES; INHIBITORS; AGENTS; ALPHA; 1,3,4-OXA(THIA)DIAZOLE; ANTICONVULSANT; SULFONAMIDES; MOIETIES; HALIDES;

D O I：

10.1080/10426500902796980

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

3-Bromoacetyl-1,5-diphenyl-1H-pyrazole-4-carbonitrile (1) reacts with sodium benzenesulfinate to give the corresponding ketosulfone 2. Treatment of 2 with hydrazonoyl chlorides 3a,b gives the 3,3'-bipyrazoles 5a,b. Ketosulfone 2 reacts also with arylidenemalononitriles to give the pyrazolylpyridones 10a,b. The reaction of compound 2 with phenylisothiocyanate and potassium hydroxide and treating intermediate with hydrazonoyl halides and with -haloketones gives the 1,3,4-thiadiazoles 18a-c and thiophenes 21a-f, respectively.

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页码：330 / 339

页数：10

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