CodY, a master integrator of metabolism and virulence in Gram-positive bacteria

被引：59

作者：

Brinsmade, Shaun R. ^{[1
]}

机构：

[1] Georgetown Univ, Dept Biol, Washington, DC 20057 USA

来源：

CURRENT GENETICS | 2017年 / 63卷 / 03期

关键词：

CodY; Regulation; Virulence; Branched-chain amino acids; BACILLUS-SUBTILIS CODY; GLOBAL REGULATOR CODY; STAPHYLOCOCCUS-AUREUS; GENE-EXPRESSION; CAPSULAR POLYSACCHARIDE; STRINGENT RESPONSE; STATIONARY-PHASE; BINDING SITES; AMINO-ACIDS; REPRESSION;

D O I：

10.1007/s00294-016-0656-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A growing body of evidence points to CodY, a global regulator in Gram-positive bacteria, as a critical link between microbial physiology and pathogenesis in diverse environments. Recent studies uncovering graded regulation of CodY gene targets reflect the true nature of this transcription factor controlled by ligands and reveal nutrient availability as a potentially critical factor in modulating pathogenesis. This review will serve to update the status of the field and raise new questions to be answered.

引用

页码：417 / 425

页数：9

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