Solubilisation of model adjuvants by Pluronic block copolymers

被引：16

作者：

Sharp, Melissa A. ^{[1
,2
]}

Washington, Clive ^{[3
]}

Cosgrove, Terence ^{[2
]}

机构：

[1] ESS Scandinavia, SE-22100 Lund, Sweden

[2] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[3] AstraZeneca, Macclesfield SK10 2NA, Cheshire, England

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2010年 / 344卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

Pluronic; P85; P105; F127; Micelle; Adjuvant; SANS; PFG-NMR; Benzyl benzoate; Benzyl alcohol; ANGLE NEUTRON-SCATTERING; NUCLEAR-MAGNETIC-RESONANCE; STUDYING TRANSLATIONAL DIFFUSION; OSCILLATORY SHEAR MEASUREMENTS; OXIDE) TRIBLOCK COPOLYMERS; AQUEOUS-SOLUTION; MICELLAR STRUCTURE; LIGHT-SCATTERING; DRUG-DELIVERY; PHASE-DIAGRAMS;

D O I：

10.1016/j.jcis.2010.01.005

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The effect of two model adjuvants (benzyl benzoate and benzyl alcohol) on the structure and dynamics of three Pluronic triblock copolymers (P85, P105 and F127) was studied using small-angle neutron scattering and pulsed-field gradient NMR. The two adjuvants studied have different aqueous solubilities. It was found that both adjuvants promoted the micellisation of the Pluronic block copolymers. In addition they lead to a swelling of the micelles, as shown by small-angle neutron scattering. From the pulsed-field gradient NMR results it was possible to determine the amount of adjuvant bound to the micelles. Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved.

引用

页码：438 / 446

页数：9

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