The Chemically Highly Diversified Metabolites from the Red Sea Marine Sponge Spongia sp.

被引：9

作者：

Tai, Chi-Jen ^{[1
]}

Ahmed, Atallah F. ^{[2
,3
]}

Chao, Chih-Hua ^{[4
,5
]}

Yen, Chia-Hung ^{[6
]}

Hwang, Tsong-Long ^{[7
,8
,9
]}

Chang, Fang-Rong ^{[6
]}

Huang, Yusheng M. ^{[10
,11
]}

Sheu, Jyh-Horng ^{[1
,6
,12
,13
]}

机构：

[1] Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 80424, Taiwan

[2] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia

[3] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

[4] China Med Univ, Sch Pharm, Taichung 406040, Taiwan

[5] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 406040, Taiwan

[6] Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan

[7] Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Taoyuan 333, Taiwan

[8] Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Grad Inst Hlth Ind Technol, Taoyuan 333, Taiwan

[9] Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan 333, Taiwan

[10] Natl Penghu Univ Sci & Technol, Dept Marine Recreat, Magong 880011, Penghu, Taiwan

[11] Natl Penghu Univ Sci & Technol, Trop Isl Sustainable Dev Res Ctr, Magong 880011, Penghu, Taiwan

[12] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[13] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404333, Taiwan

来源：

MARINE DRUGS | 2022年 / 20卷 / 04期

关键词：

Red Sea sponge; Spongia sp; halogenated labdane diterpenoid; polyoxygenated steroid; fatty acid; polychlorinated metabolites; cytotoxicity; antibacterial assay; anti-inflammatory assay; INHIBITS SUPEROXIDE-PRODUCTION; HALOGENATED METABOLITES; ANTIBACTERIAL ACTIVITY; HUMAN NEUTROPHILS; ELASTASE RELEASE; LAURENCIA; ALGA; DITERPENES; SESQUITERPENES; RING;

D O I：

10.3390/md20040241

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A polyoxygenated and halogenated labdane, spongianol (1); a polyoxygenated steroid, 3 beta,5 alpha,9 alpha-trihydroxy-24S-ethylcholest-7-en-6-one (2); a rare seven-membered lactone B ring, (22E,24S)-ergosta-7,22-dien-3 beta,5 alpha-diol-6,5-olide (3); and an alpha,beta-unsaturated fatty acid, (Z)-3-methyl-9-oxodec-2-enoic acid (4) as well as five known compounds, 10-hydroxykahukuene B (5), pacifenol (6), dysidamide (7), 7,7,7-trichloro-3-hydroxy-2,2,6-trimethyl-4-(4,4,4-trichloro-3-methyl-1-oxobu-tylamino)-heptanoic acid methyl ester (8), and the primary metabolite 2'-deoxynucleoside thymidine (9), have been isolated from the Red Sea sponge Spongia sp. The stereoisomer of 3 was discovered in Ganoderma resinaceum, and metabolites 5 and 6, isolated previously from red algae, were characterized unprecedentedly in the sponge. Compounds 7 and 8 have not been found before in the genus Spongia. Compounds 1-9 were also assayed for cytotoxicity as well as antibacterial and anti-inflammatory activities.

引用

页数：14

共 59 条

[1] Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp. [J].