Contact dermatitis with clostridiopeptidase A contained in Noruxol® ointment

被引:4
作者
Foti, Caterina [1 ]
Conserva, Anna [1 ]
Casulli, Claudia [1 ]
Scrimieri, Valentina [1 ]
Pepe, Maria Luisa [1 ]
Quaranta, Domenico [1 ]
机构
[1] Univ Bari, Policlin, Dept Internal Med Immunol & Infect Dis, Unit Dermatol, I-70124 Bari, Italy
关键词
clostridiopeptidase A; contact dermatitis; Noruxol (R); ulcer;
D O I
10.1111/j.1600-0536.2006.01056.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Clostridiopeptidase A, also called collagenase 1, is a proteolytic enzyme capable of digesting collagen. Preparations containing clostridiopeptidase A are used topically for the debridement of dermal ulcers, burns and other necrotic lesions to facilitate the formation of granulation tissue and subsequent epithelization. We observed 4 patients with a periulcerative eczema after repeated applications of Noruxol (R) ointment (Smith & Nephew Ltd, L Hull, UK). Patch testing with Noruxol (R) ointment as is and its excipients (soft paraffin and white petrolatum), as well as scaled dilutions of the main ingredient of this topical preparation, clostridiopeptidase A (Firma, Florence, Italy), showed doubtful reactions to Noruxol (R) ointment in 3 patients and a positive reactions only in 1 patient. All patients showed positive reactions to clostridiopeptidase A 1% in pet. This study shows the sensitizing capacity of clostridiopeptidase A that should be tested in all patients with suspect sensitization to Noruxol (R) ointment.
引用
收藏
页码:361 / 362
页数:2
相关论文
共 2 条
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