Quality of life and functional status in patients with cancer of the oral cavity and oropharynx: pretreatment values of a prospective study

被引:65
作者
Borggreven, Pepijn A.
Verdonck-de Leeuw, Irma M.
Muller, Martin J.
Heiligers, Milou L. C. H.
de Bree, Remco
Aaronson, Neil K.
Leemans, C. Rene
机构
[1] VU Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, NL-1007 MB Amsterdam, Netherlands
[2] Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands
关键词
head and neck cancer; quality of life; functional status; speech; microvascular reconstruction;
D O I
10.1007/s00405-007-0249-5
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
We assessed the pretreatment health-related quality of life (HRQOL) and functional status of patients with advanced oral and oropharyngeal cancer. Eighty patients were investigated. HRQOL was assessed by EORTC QLQ-C30/QLQ-H&N35 questionnaires. Functional status assessment comprised speech and oral function tests. The results revealed a wide range of HRQOL and functional deficits before treatment. HRQOL appeared to be related to some extent to tumor site (patients with oral tumors reported more pain compared to patients with oropharyngeal tumors) and tumor classification (patients with T3-T4 tumors reported more trouble opening the mouth and felt more ill compared to patients with T2 tumors). Comorbidity appeared to have a major impact. Patients with comorbidity had significantly worse scores on several scales/items on both the EORTC questionnaires. Functional deficits were related to tumor site, classification and comorbidity. Patients with oral cavity tumors (versus oropharyngeal tumors), patients with T3-T4 tumors (versus T2 tumors), and patients with comorbidity (versus without comorbidity) scored significantly worse on several speech and oral function tests. Impaired speech and oral function appeared to be clearly related to global quality of life (QLQ-C30) and self-reported speech (QLQ-H&N35). Many patients with advanced oral and oropharyngeal cancer have compromised HRQOL and functional status before the start of treatment. In addition to tumor site and tumor classification, comorbidity appears to have a major impact on HRQOL and functional status. Knowledge of pretreatment HRQOL and functional status levels is useful for better understanding the impact of treatment on these outcomes over time.
引用
收藏
页码:651 / 657
页数:7
相关论文
共 33 条
[1]   THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER QLQ-C30 - A QUALITY-OF-LIFE INSTRUMENT FOR USE IN INTERNATIONAL CLINICAL-TRIALS IN ONCOLOGY [J].
AARONSON, NK ;
AHMEDZAI, S ;
BERGMAN, B ;
BULLINGER, M ;
CULL, A ;
DUEZ, NJ ;
FILIBERTI, A ;
FLECHTNER, H ;
FLEISHMAN, SB ;
DEHAES, JCJM ;
KAASA, S ;
KLEE, M ;
OSOBA, D ;
RAZAVI, D ;
ROFE, PB ;
SCHRAUB, S ;
SNEEUW, K ;
SULLIVAN, M ;
TAKEDA, F .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (05) :365-376
[2]   Health-related quality of life associated with chronic conditions in eight countries:: Results from the International Quality of Life Assessment (IQOLA) Project [J].
Alonso, J ;
Ferrer, M ;
Gandek, B ;
Ware, JE ;
Aaronson, NK ;
Mosconi, P ;
Rasmussen, NK ;
Bullinger, M ;
Fukuhara, S ;
Kaasa, S ;
Leplège, A .
QUALITY OF LIFE RESEARCH, 2004, 13 (02) :283-298
[3]   Quality of life in head and neck cancer patients:: Validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire -: H&N35 [J].
Bjordal, K ;
Hammerlid, E ;
Ahlner-Elmqvist, M ;
de Graeff, A ;
Boysen, M ;
Evensen, JF ;
Biörklund, A ;
de Leeuw, JRJ ;
Fayers, PM ;
Jannert, M ;
Westin, T ;
Kaasa, S .
JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (03) :1008-1019
[4]   A prospective study of quality of life in head and neck cancer patients.: Part II:: Longitudinal data [J].
Bjordal, K ;
Ahlner-Elmqvist, M ;
Hammerlid, E ;
Boysen, M ;
Evensen, JF ;
Biörklund, A ;
Jannert, M ;
Westin, T ;
Kaasa, S .
LARYNGOSCOPE, 2001, 111 (08) :1440-1452
[5]   Severe comorbidity negatively influences prognosis in patients with oral and oropharyngeal cancer after surgical treatment with microvascular reconstruction [J].
Borggreven, PA ;
Kuik, DJ ;
Langendijk, JA ;
Doornaert, P ;
de Bree, R ;
Leemans, CR .
ORAL ONCOLOGY, 2005, 41 (04) :358-364
[6]   Comorbid condition as a prognostic factor for complications in major surgery of the oral cavity and oropharynx with microvascular soft tissue reconstruction [J].
Borggreven, PA ;
Kuik, DJ ;
Quak, JJ ;
de Bree, R ;
Snow, GB ;
Leemans, CR .
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2003, 25 (10) :808-815
[7]  
Colangelo LA, 1996, HEAD NECK-J SCI SPEC, V18, P259
[8]  
de Graeff A, 2000, HEAD NECK-J SCI SPEC, V22, P398, DOI 10.1002/1097-0347(200007)22:4<398::AID-HED14>3.0.CO
[9]  
2-V
[10]  
Derks Wynia, 2005, Curr Opin Otolaryngol Head Neck Surg, V13, P92, DOI 10.1097/01.moo.0000156169.63204.39