Platelet Physiology

被引：289

作者：

Gremmel, Thomas ^{[1
,2
]}

Frelinger, Andrew L., III ^{[1
]}

Michelson, Alan D. ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Boston Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA

[2] Med Univ Vienna, Dept Internal Med 2, Vienna, Austria

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2016年 / 42卷 / 03期

关键词：

platelet function; platelet structure; platelet granules; platelet surface glycoproteins; platelet activation pathways; platelet physiology; review; GLYCOPROTEIN-IIB-IIIA; LYSOSOME-RELATED ORGANELLES; OPEN CANALICULAR SYSTEM; IX-V COMPLEX; PROTEASE-ACTIVATED RECEPTORS; ELECTRON-DENSE CHAINS; HUMAN-BLOOD-PLATELETS; ALPHA-GRANULES; THROMBUS FORMATION; MULTIVESICULAR BODIES;

D O I：

10.1055/s-0035-1564835

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelets are the smallest blood cells, numbering 150 to 350 x 10(9)/L in healthy individuals. The ability of activated platelets to adhere to an injured vessel wall and form aggregates was first described in the 19th century. Besides their long-established roles in thrombosis and hemostasis, platelets are increasingly recognized as pivotal players in numerous other pathophysiological processes including inflammation and atherogenesis, antimicrobial host defense, and tumor growth and metastasis. Consequently, profound knowledge of platelet structure and function is becoming more important in research and in many fields of modern medicine. This review provides an overview of platelet physiology focusing particularly on the structure, granules, surface glycoproteins, and activation pathways of platelets.

引用

页码：191 / 204

页数：14

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