Nanopores formed by DNA origami: A review

被引：73

作者：

Bell, Nicholas A. W. ^{[1
]}

Keyser, Ulrich F. ^{[1
]}

机构：

[1] Univ Cambridge, Cavendish Lab, Cambridge CB3 0HE, England

来源：

FEBS LETTERS | 2014年 / 588卷 / 19期

基金：

英国工程与自然科学研究理事会;

关键词：

Nanopores; DNA origami; Self-assembly; Single molecule; Nanotechnology; ALPHA-HEMOLYSIN; STRANDED-DNA; FOLDING DNA; NANOSTRUCTURES; TRANSLOCATION; CHALLENGES; TRANSPORT; PROTEINS; CHANNELS; SHAPES;

D O I：

10.1016/j.febslet.2014.06.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nanopores have emerged over the past two decades to become an important technique in single molecule experimental physics and biomolecule sensing. Recently DNA nanotechnology, in particular DNA origami, has been used for the formation of nanopores in insulating materials. DNA origami is a very attractive technique for the formation of nanopores since it enables the construction of 3D shapes with precise control over geometry and surface functionality. DNA origami has been applied to nanopore research by forming hybrid architectures with solid state nanopores and by direct insertion into lipid bilayers. This review discusses recent experimental work in this area and provides an outlook for future avenues and challenges. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3564 / 3570

页数：7

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