Dumulmycin, an Antitubercular Bicyclic Macrolide from a Riverine Sediment-Derived Streptomyces sp.

被引：24

作者：

An, Joon Soo ^{[1
]}

Shin, Bora ^{[1
]}

Kim, Tae Ho ^{[2
]}

Hwang, Sunghoon ^{[1
]}

Shin, Yern-Hyerk ^{[1
]}

Cui, Jinsheng ^{[1
]}

Du, Young Eun ^{[1
]}

Yi, Jungwoo ^{[1
]}

Nam, Sang-Jip ^{[3
]}

Hong, Suckchang ^{[4
]}

Shin, Jongheon ^{[1
]}

Jang, Jichan ^{[2
]}

Yoon, Yeo Joon ^{[1
]}

Oh, Dong-Chan ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Nat Prod Res Inst, Seoul 08826, South Korea

[2] Gyeongsang Natl Univ, Res Inst Life Sci, Div Bio & Med,Big Data Dept,BK4 Program, Div Life Sci,Mol Mech Antibiot, Gyeongnam 52828, South Korea

[3] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea

[4] Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 08826, South Korea

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

BIOSYNTHETIC GENE-CLUSTER; ABSOLUTE-CONFIGURATION; POLYKETIDE; SEQUENCE; NMR; HITACHIMYCIN; MECHANISM;

D O I：

10.1021/acs.orglett.1c00847

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dumulmycin (1) was isolated from Streptomyces sp. DM28, a bacterial strain from a riverine sediment sample. The structure of 1 was elucidated as a bicyclic macrolide possessing 19-membered and 5-membered rings by spectroscopic analysis. The stereochemistry of 1 was determined by J-based configuration analysis, ROESY NMR data, DP4 calculations, and the modified Mosher's method. Genetic analysis identified a trans-acyltransferase polyketide biosynthetic gene cluster for 1. Dumulmycin exhibited in vitro antitubercular activity (MIC50 = 27.1 mu M).

引用

页码：3359 / 3363

页数：5

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