Androgen Deprivation Therapy Use and Risk of Mild Cognitive Impairment in Prostate Cancer Patients

被引:6
作者
Alonso-Quinones, Hector [1 ,2 ,3 ]
Stish, Bradley J. [4 ]
Aakre, Jeremiah A. [5 ]
Hagen, Clinton E. [5 ]
Petersen, Ronald C. [5 ,6 ]
Mielke, Michelle M. [5 ,6 ]
机构
[1] Univ Puerto Rico, Sch Med, San Juan, PR 00936 USA
[2] Mayo Clin, Alix Sch Med, Rochester, MN USA
[3] Mayo Clin, Ctr Clin & Translat Sci, Rochester, MN USA
[4] Mayo Clin, Dept Radiat Oncol, Rochester, MN USA
[5] Mayo Clin, Dept Hlth Sci Res, 200 First St Southwest, Rochester, MN 55905 USA
[6] Mayo Clin, Dept Neurol, Rochester, MN USA
关键词
prostate cancer; cognition; longitudinal study; HORMONE; MEN;
D O I
10.1097/WAD.0000000000000415
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction: We examined the association between androgen deprivation therapy (ADT) use and the risk of mild cognitive impairment (MCI) among prostate cancer patients. Methods: We included 241 cognitively unimpaired men, aged 70 to 90, with a history of prostate cancer before enrollment in the population-based Mayo Clinic Study of Aging. Using the Rochester Epidemiology Project medical records-linkage system, ADT use and length of exposure were abstracted. Follow-up visits occurred every 15 months and MCI diagnoses were made based on clinical consensus. Cox proportional hazards models, with age as the timescale, were used to examine the association between ADT use (yes/no) and length of exposure with the risk of MCI adjusting for education, apolipoprotein E, depression, and the Charlson Index score. Results: There was no association between any ADT use (27.8% of participants) and the risk of MCI in the multivariable model [hazard ratio (HR), 1.25; 95% confidence interval (CI), 0.75-2.10]. Although not significant, there was an ADT dose-response relationship for risk of MCI: <5 years versus no use (HR, 1.08; 95% CI, 0.60-1.96) and <greater than or equal to>5 years versus not use (HR, 1.89; 95% CI, 0.83-4.27). Conclusion: ADT use among prostate cancer patients was not associated with an increased risk of developing MCI.
引用
收藏
页码:44 / 47
页数:4
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