Negativization of antinuclear, anti-dsDNA, and anti-chromatin antibodies after vitamin D supplementation in a lupus patient

被引：2
作者：
de Carvalho, J. F. [1 ]
机构：
[1] Univ Fed Bahia, Inst Hlth Sci, Rua Das Violetas 42,Ap 502, Salvador, BA, Brazil
来源：
CLINICAL NUTRITION ESPEN | 2021年 / 42卷
关键词：
Vitamin D; Systemic lupus erythematosus; Disease activity; Antinuclear antibodies; Autoimmunity; Autoantibodies; anti-dsDNA; Anti-chromatin; DISEASE-ACTIVITY; ASSOCIATION; SLE;
D O I：
10.1016/j.clnesp.2021.01.025
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Background: A previous study have evaluated that antinuclear antibodies (ANA) negativization is linked to low lupus disease activity. Aim: To describe a lupus patient who evolved with negativization of ANA, anti-dsDNA, and antichromatin antibodies after vitamin D supplementation. Method: Case report. Results: A 56-year-old female patient, diagnosed with systemic lupus erythematosus since 2015 characterized by typical malar erythema, photosensitivity, polyarthritis, leucopenia, positive antinuclear antibody, anti-dsDNA, and anti-chromatin antibody. She received hydroxychloroquine and prednisone. After 1 year, corticotherapy was tapered off, and no clinical evidence of lupus activity was registered (SLEDAI = 0). However, ANA remained positive with a titer of 1:640 with a homogeneous pattern, and positive anti-dsDNA 1/20 and anti-chromatin 97 Units (normal range: <20 Units) remained all-time positive. Treatment with vitamin D 25,000 IU/day was initiated, and during follow-up, anti-chromatin and anti-dsDNA disappeared. In 2019, the patient was asymptomatic, keeping SLEDAI = 0, negative antidsDNA and anti-chromatin, and surprisingly the ANA turned negative, which was confirmed on several occasions until now. Conclusion: This case adds knowledge to the understanding that negative antinuclear antibodies appear to be associated with a better prognosis in lupus patients. Furthermore, the use of vitamin D seems to be a complementary therapeutic tool for this purpose. (C) 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights
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页码：262 / 264
页数：3
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