Early-onset Alzheimer's disease is associated with greater pathologic burden

被引：107

作者：

Marshall, Gad A. ^{[1
]}

Fairbanks, Lynn A. ^{[1
]}

Tekin, Sibel ^{[1
]}

Vinters, Harry V. ^{[1
]}

Cummings, Jeffrey L. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Florham Pk, NJ USA

来源：

JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY | 2007年 / 20卷 / 01期

关键词：

Alzheimer's disease; early onset; late onset; pathology; neuritic plaques; neurofibrillary tangles;

D O I：

10.1177/0891988706297086

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Two subtypes of Alzheimer's disease (AD) have been commonly identified: early- and late-onset forms. Previous studies suggest that early-onset AD patients have more neuritic plaques (NPs) and neurofibrillary tangles (NFTs). In the current study, NP and NFT counts were performed for 8 brain regions in 25 subjects with definite AD. A repeated-measures analysis of variance of mean regional NP and NFT counts for early- and late-onset groups was performed. A significant between-subject effect indicating greater overall NP and NFT burden in the early-onset group was observed (NP: F = 6.8, df = 1, P =.015; NFT: F = 7.5, df = 1, P =.012). This analysis supports the hypothesis that early-onset AD is associated with greater pathologic burden than late-onset AD. This suggests that late-onset AD patients have less cognitive reserve than early-onset patients and require fewer pathologic changes to exhibit cognitive deterioration.

引用

页码：29 / 33

页数：5

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