Negative regulation of TCR signaling and T-cell activation by selective protein degradation

被引：38

作者：

Jang, IK ^{[1
]}

Gu, H ^{[1
]}

机构：

[1] NIAID, Immunol Lab, Rockville, MD 20852 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(03)00048-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Protein degradation was previously considered to be a nonspecific cellular process that eradicated abnormal or damaged proteins. Current evidence indicates, however, that T cells use this mechanism to selectively eliminate activated T-cell receptors (TCRs) and signaling molecules, and consequently control the duration and specificity of TCR signaling.

引用

页码：315 / 320

页数：6

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