Tapentadol extended release in the management of peripheral diabetic neuropathic pain

被引:30
作者
Vadivelu, Nalini [1 ]
Kai, Alice [2 ]
Maslin, Benjamin [1 ]
Kodumudi, Gopal [3 ]
Legler, Aron [1 ]
Berger, Jack M. [4 ]
机构
[1] Yale Univ, Sch Med, Dept Anesthesiol, New Haven, CT 06520 USA
[2] SUNY Stony Brook, Sch Med, Stony Brook, NY 11794 USA
[3] Tulane Univ, Dept Struct & Cellular Biol, New Orleans, LA 70118 USA
[4] Univ So Calif, Keck Sch Med, Dept Anesthesiol, Los Angeles, CA 90033 USA
关键词
chronic pain; neuropathic pain; pharmacology; analgesia; pain management; OPIOID RECEPTOR AGONIST; LOW-BACK-PAIN; OXYCODONE CONTROLLED-RELEASE; RANDOMIZED CONTROLLED-TRIAL; INDUCED BOWEL DYSFUNCTION; DOUBLE-BLIND; PROLONGED-RELEASE; CHRONIC OSTEOARTHRITIS; PHARMACOLOGICAL MANAGEMENT; MORPHINE ANALGESIA;
D O I
10.2147/TCRM.S32193
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Tapentadol, a mu-opioid agonist and norepinephrine reuptake inhibitor, has been found to be an effective medication for a wide variety of chronic pain conditions, including back pain, cancer-related pain, and arthritic pain. It has also been found to have fewer gastrointestinal side effects than more traditional opioid-based therapies. More recently, tapentadol extended release has been demonstrated to be effective in the management of painful diabetic neuropathy, an often debilitating condition affecting approximately one-third of all patients with diabetes. This review highlights the most up-to-date basic and clinical studies by focusing on the mechanisms of action of tapentadol and its clinical efficacy, especially with regard to painful diabetic neuropathy.
引用
收藏
页码:95 / 105
页数:11
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