Ceftazidime-Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae

被引：10
作者：
Ding, Li [1 ,2 ]
Shen, Siquan [1 ,2 ]
Han, Renru [1 ,2 ]
Yin, Dandan [1 ,2 ]
Guo, Yan [1 ,2 ]
Hu, Fupin [1 ,2 ]
机构：
[1] Fudan Univ, Huashan Hosp, Inst Antibiot, Shanghai 200040, Peoples R China
[2] Minist Hlth, Key Lab Clin Pharmacol Antibiot, Shanghai 200040, Peoples R China
来源：
ANTIBIOTICS-BASEL | 2022年 / 11卷 / 05期
基金：
中国国家自然科学基金;
关键词：
KPC-2; KPC-33; ceftazidime-avibactam; imipenem; RESISTANCE; EMERGENCE;
D O I：
10.3390/antibiotics11050604
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
A 22-year-old man, after a hematopoietic stem cell transplant, suffered long-term pneumonia caused by bla(KPC-2)-positive K. pneumoniae and bla(KPC-33-)positive K. pneumoniae alternately and finally achieved pathogenic clearance and improvement of clinical infectious conditions after using ceftazidime-avibactam in combination with imipenem as salvage therapy. This case provides a reference for treating infection caused by K. pneumoniae with a KPC variant in countries lacking new antimicrobial agents.
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页数：6
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