CENTRAL AORTIC PRESSURE;
BODY IMPEDANCE CARDIOGRAPHY;
CENTRAL PULSE PRESSURE;
ARTERIAL STIFFNESS;
BLOOD-PRESSURE;
WAVE REFLECTION;
HEART-FAILURE;
BETA-BLOCKERS;
ATENOLOL;
AMLODIPINE;
D O I:
10.1111/bcpt.12771
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Treatment with beta-blockers appears to show inferior reduction in central versus peripheral blood pressure. We aimed to examine simultaneous changes in central and peripheral blood pressure, vascular resistance, cardiac function and arterial stiffness during beta-blockade. Haemodynamics were investigated after 3 weeks of bisoprolol treatment (5 mg/day) in a double-blind, randomized, placebo-controlled cross-over trial in never-treated 16 Caucasian males with grade I-II primary hypertension using continuous tonometric pulse wave analysis and whole-body impedance cardiography. Bisoprolol decreased radial (134/80 versus 144/89 mmHg) and aortic blood pressure (122/80 versus 130/90 mmHg) and heart rate (57 versus 68 beats/min) when compared with placebo (p < 0.05 for all). Ejection duration (336 versus 316 ms) and stroke volume (109 versus 98 ml) were increased (p < 0.01 for all), while cardiac output was not significantly changed (6.2 versus 6.6 l/min). Bisoprolol decreased pulse wave velocity (7.8 versus 8.9 m/s, p < 0.001), but after adjustment for blood pressure, the decrease was not significant (8.16 versus 8.52 m/s, p = 0.464). The treatment reduced pulse pressure amplification from central to peripheral circulation (30 versus 38%, p = 0.002). No differences were observed in systemic vascular resistance, augmentation index, aortic characteristic impedance or total arterial stiffness after bisoprolol versus placebo. Bisoprolol decreased central and peripheral blood pressure and pulse wave velocity in male individuals with grade I to grade II hypertension. The decrease in pulse wave velocity was related to the antihypertensive effect. Reduced pulse pressure amplification indicates that peripheral blood pressure was reduced more efficiently than central blood pressure.
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Aparicio, Lucas S.
;
Alfie, Jose
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Alfie, Jose
;
Barochiner, Jessica
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Barochiner, Jessica
;
Cuffaro, Paula E.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Cuffaro, Paula E.
;
Giunta, Diego H.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Internal Med Res Unit, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Giunta, Diego H.
;
Elizondo, Cristina M.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Internal Med Res Unit, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Elizondo, Cristina M.
;
Tortella, Juan J.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Family Med, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Tortella, Juan J.
;
Morales, Margarita S.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Morales, Margarita S.
;
Rada, Marcelo A.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Rada, Marcelo A.
;
Waisman, Gabriel D.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
机构:
Univ Chicago, Med Ctr, Dept Med, Hypertens Dis Unit, Chicago, IL 60637 USAUniv Chicago, Med Ctr, Dept Med, Hypertens Dis Unit, Chicago, IL 60637 USA
机构:
Univ Paris 05, Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Dept Pharmacol,INSERM,U970,Team 7, F-75015 Paris, FranceUniv Paris 05, Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Dept Pharmacol,INSERM,U970,Team 7, F-75015 Paris, France
Boutouyrie, Pierre
;
Achouba, Assya
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Pharmaceut, Paris, FranceUniv Paris 05, Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Dept Pharmacol,INSERM,U970,Team 7, F-75015 Paris, France
Achouba, Assya
;
Trunet, Patrick
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Pharmaceut, Paris, FranceUniv Paris 05, Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Dept Pharmacol,INSERM,U970,Team 7, F-75015 Paris, France
Trunet, Patrick
;
Laurent, Stephane
论文数: 0引用数: 0
h-index: 0
机构:Univ Paris 05, Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Dept Pharmacol,INSERM,U970,Team 7, F-75015 Paris, France
机构:
Kings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, EnglandKings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, England
Cecelja, Marina
;
Chowienczyk, Philip
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, EnglandKings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, England
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Aparicio, Lucas S.
;
Alfie, Jose
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Alfie, Jose
;
Barochiner, Jessica
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Barochiner, Jessica
;
Cuffaro, Paula E.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Cuffaro, Paula E.
;
Giunta, Diego H.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Internal Med Res Unit, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Giunta, Diego H.
;
Elizondo, Cristina M.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Internal Med Res Unit, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Elizondo, Cristina M.
;
Tortella, Juan J.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Family Med, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Tortella, Juan J.
;
Morales, Margarita S.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Morales, Margarita S.
;
Rada, Marcelo A.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
Rada, Marcelo A.
;
Waisman, Gabriel D.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, ArgentinaHosp Italiano Buenos Aires, Dept Internal Med, Hypertens Sect, Buenos Aires, DF, Argentina
机构:
Univ Chicago, Med Ctr, Dept Med, Hypertens Dis Unit, Chicago, IL 60637 USAUniv Chicago, Med Ctr, Dept Med, Hypertens Dis Unit, Chicago, IL 60637 USA
机构:
Univ Paris 05, Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Dept Pharmacol,INSERM,U970,Team 7, F-75015 Paris, FranceUniv Paris 05, Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Dept Pharmacol,INSERM,U970,Team 7, F-75015 Paris, France
Boutouyrie, Pierre
;
Achouba, Assya
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Pharmaceut, Paris, FranceUniv Paris 05, Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Dept Pharmacol,INSERM,U970,Team 7, F-75015 Paris, France
Achouba, Assya
;
Trunet, Patrick
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Pharmaceut, Paris, FranceUniv Paris 05, Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Dept Pharmacol,INSERM,U970,Team 7, F-75015 Paris, France
Trunet, Patrick
;
Laurent, Stephane
论文数: 0引用数: 0
h-index: 0
机构:Univ Paris 05, Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Dept Pharmacol,INSERM,U970,Team 7, F-75015 Paris, France
机构:
Kings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, EnglandKings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, England
Cecelja, Marina
;
Chowienczyk, Philip
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, EnglandKings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, England