The structure and mechanism of the action of type-IB DNA topoisomerases

被引：0

作者：

Bugreev, D. V. ^{[1
]}

Nevinsky, G. A. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia

[2] Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Novosibirsk 630090, Russia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2010年 / 36卷 / 03期

关键词：

DNA topoisomerases; protein-nucleic acid interactions; mechanisms of enzyme action; HIGH-AFFINITY INTERACTION; N-TERMINAL DOMAIN; VACCINIA TOPOISOMERASE; SUPERCOILED DNA; CATALYTIC-ACTIVITY; ILLEGITIMATE RECOMBINATION; ENZYME INTERACTION; CRYSTAL-STRUCTURE; CLEAVAGE SITES; MUTANT ALLELES;

D O I：

10.1134/S1068162010030015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA topoisomerases responsible for the superspiralization of genomic DNA participate in almost all vitally important cell processes, including replication, transcription, and recombination, and are essential for normal cell functioning. The present review summarizes published data for type-IB topoisomerases. The results concerning the thermodynamic, structural, and kinetic aspects of the functioning of topoisomerases and the peculiarities of the mechanisms of their action have been analyzed for the first time.

引用

页码：269 / 286

页数：18

共 111 条

[1]

ALSNER J, 1992, J BIOL CHEM, V267, P12408

[2]

Andersen A H, 1994, Adv Pharmacol, V29A, P83

[3] TOPOISOMERASE-I HAS A STRONG BINDING PREFERENCE FOR A CONSERVED HEXADECAMERIC SEQUENCE IN THE PROMOTOR REGION OF THE RIBOSOMAL-RNA GENE FROM TETRAHYMENA-PYRIFORMIS [J].