Pretransplant interferon prevents hepatitis C virus-associated glomerulonephritis in renal allografts by HCV-RNA clearance

被引:87
作者
Cruzado, JM
Casanovas-Taltavull, T
Torras, J
Baliellas, C
Gil-Vernet, S
Grinyó, JM [1 ]
机构
[1] Univ Barcelona, Bellvitge Hosp, LHosp Llobregat, Dept Nephrol,Dept Med, Barcelona, Spain
[2] Univ Barcelona, Bellvitge Hosp, LHosp Llobregat, Hepatol & Gastroenterol Dept,Dept Med, Barcelona, Spain
关键词
glomerulonephritis; hepatitis C virus; interferon treatment; renal transplantation;
D O I
10.1034/j.1600-6143.2003.00057.x
中图分类号
R61 [外科手术学];
学科分类号
摘要
The purpose of this study was to examine the effect of pretransplant interferon administration on the occurrence of post-transplant de novo glomerulonephritis in hepatitis C virus (HCV)-positive renal allografts. From December 1992 to December 2000, 78 HCV-positive patients received a renal allograft in our unit. Fifteen out of 78 received pretransplant interferon for 1 year. Hepatitis C virus was investigated by serology and qualitative polymerase chain reaction (PCR). Hepatitis C virus-related de novo glomerulonephritis (membranoproliferative or membranous) was suggested by proteinuria (>1.5g/24h) and/or microhematuria and always diagnosed by renal biopsy. Of 15 HCV-positive recipients who received pretransplant interferon, 10 (67%) became HCV-RNA negative at the time of transplantation and only one out of the 15(6.7%) developed denovogiomerulo-nephritis (this patient was HCV-RNA positive at transplantation). Among non-interferon-treated allograft recipients, 28.7% had negative HCV-RNA and 12 out of 63 (19%) developed de novo glomerulonephritis (9, membranoproliferative; 3 membranous), all 12 having positive HCV-RNA at transplantation (p < 0.0001). In conclusion, pretransplant interferon may reduce the occurrence of post-transplant HCV-related de novo glomerulonephritis. Our results suggest that the indication for pretransplant interferon should be extended to treat all HCV-RNA positive candidates for renal transplantation.
引用
收藏
页码:357 / 360
页数:4
相关论文
共 11 条
[1]   Outcome of hepatitis C virus-associated membranoproliferative glomerulonephritis after liver transplantation [J].
Cantarell, MC ;
Charco, R ;
Capdevila, L ;
Vargas, V ;
Lazaro, JL ;
Murio, E ;
Piera, L ;
Margarit, C .
TRANSPLANTATION, 1999, 68 (08) :1131-1134
[2]  
Casanovas-Taltavull T, 2001, AM J GASTROENTEROL, V96, P1170
[3]   Hepatitis C links hepatologists, nephrologists,and transplant surgeons [J].
Crosbie, O .
TRANSPLANTATION, 1999, 68 (08) :1094-1095
[4]   Hepatitis C virus infection and de novo glomerular lesions in renal allografts [J].
Cruzado, JM ;
Carrera, M ;
Torras, J ;
Grinyó, JM .
AMERICAN JOURNAL OF TRANSPLANTATION, 2001, 1 (02) :171-178
[5]   Glomerulonephritis associated with hepatitis C virus infection after renal transplantation [J].
Cruzado, JM ;
Torras, J ;
Gil-Vernet, S ;
Grinyó, JM .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2000, 15 :65-67
[6]  
Cruzado JM, 1996, J AM SOC NEPHROL, V7, P2469
[7]  
Morales JM, 2000, J AM SOC NEPHROL, V11, P1343, DOI 10.1681/ASN.V1171343
[8]   Management of hepatitis C infection in renal transplant recipients [J].
Natov, SN ;
Pereira, BJG .
AMERICAN JOURNAL OF TRANSPLANTATION, 2002, 2 (06) :483-490
[9]   Effects of ribavirin on hepatitis C-associated nephrotic syndrome in four liver transplant recipients [J].
Pham, HP ;
Féray, C ;
Samuel, D ;
Gigou, M ;
Azoulay, D ;
Paradis, V ;
Ducret, F ;
Charpentier, B ;
Debuire, B ;
Lemoine, A .
KIDNEY INTERNATIONAL, 1998, 54 (04) :1311-1319
[10]  
Rostaing L, 1998, J AM SOC NEPHROL, V9, P2344