Telomerase Expression by Aberrant Methylation of the TERT Promoter in Melanoma Arising in Giant Congenital Nevi

被引：36
作者：
Fan, Yiping [1 ]
Lee, Seungjae [2 ]
Wu, Gang [1 ]
Easton, John [1 ]
Yergeau, Donald [1 ]
Dummer, Reinhard [3 ]
Vogel, Peter [2 ]
Kirkwood, John M. [4 ]
Barnhill, Raymond L. [5 ]
Pappo, Alberto [6 ]
Bahrami, Armita [2 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 USA
[2] St Jude Childrens Res Hosp, Dept Pathol, 332 N Lauderdale St, Memphis, TN 38105 USA
[3] Univ Zurich Hosp, Dept Dermatol, Gloriastr 31, CH-8091 Zurich, Switzerland
[4] Univ Pittsburgh, Med Ctr, Div Hematol Oncol, Pittsburgh, PA USA
[5] Inst Curie, Dept Pathol, Paris, France
[6] St Jude Childrens Res Hosp, Dept Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2016年 / 136卷 / 01期
关键词：
DNA METHYLATION; CELL-LINES; HTERT GENE; MUTATIONS; CANCER; CHILDHOOD; RISK;
D O I：
10.1038/JID.2015.374
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
[No abstract available]
引用
收藏
页码：339 / 342
页数：4
相关论文
共 15 条
  • [1] The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer
    Bell, Robert J. A.
    Rube, H. Tomas
    Kreig, Alex
    Mancini, Andrew
    Fouse, Shaun D.
    Nagarajan, Raman P.
    Choi, Serah
    Hong, Chibo
    He, Daniel
    Pekmezci, Melike
    Wiencke, John K.
    Wrensch, Margaret R.
    Chang, Susan M.
    Walsh, Kyle M.
    Myong, Sua
    Song, Jun S.
    Costello, Joseph F.
    [J]. SCIENCE, 2015, 348 (6238) : 1036 - 1039
  • [2] Large congenital melanocytic nevi and the risk for development of malignant melanoma and neurocutaneous melanocytosis
    Bittencourt, FV
    Marghoob, AA
    Kopf, AW
    Koenig, KL
    Bart, RS
    [J]. PEDIATRICS, 2000, 106 (04) : 736 - 741
  • [3] STRUCTURE AND FUNCTION OF TELOMERES
    BLACKBURN, EH
    [J]. NATURE, 1991, 350 (6319) : 569 - 573
  • [4] Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study
    Castelo-Branco, Pedro
    Choufani, Sanaa
    Mack, Stephen
    Gallagher, Denis
    Zhang, Cindy
    Lipman, Tatiana
    Zhukova, Nataliya
    Walker, Erin J.
    Martin, Dianna
    Merino, Diana
    Wasserman, Jonathan D.
    Elizabeth, Cynthia
    Alon, Noa
    Zhang, Libo
    Hovestadt, Volker
    Kool, Marcel
    Jones, David T. W.
    Zadeh, Gelareh
    Croul, Sidney
    Hawkins, Cynthia
    Hitzler, Johann
    Wang, Jean C. Y.
    Baruchel, Sylvain
    Dirks, Peter B.
    Malkin, David
    Pfister, Stefan
    Taylor, Michael D.
    Weksberg, Rosanna
    Tabori, Uri
    [J]. LANCET ONCOLOGY, 2013, 14 (06) : 534 - 542
  • [5] Unusual distribution of DNA methylation within the hTERT CpG island in tissues and cell lines
    Guilleret, I
    Benhattar, J
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 325 (03) : 1037 - 1043
  • [6] Demethylation of the human telomerase catalytic subunit (hTERT) gene promoter reduced hTERT expression and telomerase activity and shortened telomeres
    Guilleret, I
    Benhattar, J
    [J]. EXPERIMENTAL CELL RESEARCH, 2003, 289 (02) : 326 - 334
  • [7] TERT Promoter Mutations in Familial and Sporadic Melanoma
    Horn, Susanne
    Figl, Adina
    Rachakonda, P. Sivaramakrishna
    Fischer, Christine
    Sucker, Antje
    Gast, Andreas
    Kadel, Stephanie
    Moll, Iris
    Nagore, Eduardo
    Hemminki, Kari
    Schadendorf, Dirk
    Kumar, Rajiv
    [J]. SCIENCE, 2013, 339 (6122) : 959 - 961
  • [8] SPECIFIC ASSOCIATION OF HUMAN TELOMERASE ACTIVITY WITH IMMORTAL CELLS AND CANCER
    KIM, NW
    PIATYSZEK, MA
    PROWSE, KR
    HARLEY, CB
    WEST, MD
    HO, PLC
    COVIELLO, GM
    WRIGHT, WE
    WEINRICH, SL
    SHAY, JW
    [J]. SCIENCE, 1994, 266 (5193) : 2011 - 2015
  • [9] TERT Promoter Mutations Are Predictive of Aggressive Clinical Behavior in Patients with Spitzoid Melanocytic Neoplasms
    Lee, Seungjae
    Barnhill, Raymond L.
    Dummer, Reinhard
    Dalton, James
    Wu, Jianrong
    Pappo, Alberto
    Bahrami, Armita
    [J]. SCIENTIFIC REPORTS, 2015, 5
  • [10] The Genomic Landscape of Childhood and Adolescent Melanoma
    Lu, Charles
    Zhang, Jinghui
    Nagahawatte, Panduka
    Easton, John
    Lee, Seungjae
    Liu, Zhifa
    Ding, Li
    Wyczalkowski, Matthew A.
    Valentine, Marcus
    Navid, Fariba
    Mulder, Heather
    Tatevossian, Ruth G.
    Dalton, James
    Davenport, James
    Yin, Zhirong
    Edmonson, Michael
    Rusch, Michael
    Wu, Gang
    Li, Yongjin
    Parker, Matthew
    Hedlund, Erin
    Shurtleff, Sheila
    Raimondi, Susana
    Bhavin, Vadodaria
    Donald, Yergeau
    Mardis, Elaine R.
    Wilson, Richard K.
    Evans, William E.
    Ellison, David W.
    Pounds, Stanley
    Dyer, Michael
    Downing, James R.
    Pappo, Alberto
    Bahrami, Armita
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2015, 135 (03) : 816 - 823
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