Jagged-1: a new promising factor associated with favorable prognosis in patients with acute myeloid leukemia

被引:12
作者
Czemerska, Magdalena [1 ]
Pluta, Agnieszka [1 ]
Szmigielska-Kaplon, Anna [1 ]
Wawrzyniak, Ewa [1 ]
Cebula-Obrzut, Barbara [2 ]
Medra, Aleksandra [2 ]
Smolewski, Piotr [2 ]
Robak, Tadeusz [1 ]
Wierzbowska, Agnieszka [1 ]
机构
[1] Med Univ Lodz, Dept Hematol, PL-93510 Lodz, Poland
[2] Med Univ Lodz, Dept Expt Hematol, PL-93510 Lodz, Poland
关键词
Myeloid leukemias and dysplasias; prognostication; signaling therapies; HUMAN HOMOLOG; NOTCH; EXPRESSION; DIAGNOSIS; GROWTH; GENE;
D O I
10.3109/10428194.2014.917638
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In this study Jagged-1 and Dll-1 surface expression as well as Notch-1 receptor intracellular domain (Notch-1-IC) expression were assessed by multi-color flow cytometry in leukemic blasts obtained from 88 patients with acute myeloid leukemia (AML). CD34+ peripheral blood stem cells (PBSCs) were used as a control. The median expression of Jagged-1 and Dll-1 was significantly higher in AML blasts than in PBSCs (p = 0.001 and p = 0.002, respectively). Higher expression of Notch-1-IC was detected in patients with poor-risk karyotype as compared to good-and intermediate-risk groups (p = 0.035). In our study, poor-risk cytogenetics and low (< median) expression of Jagged-1 were the only factors associated with significantly shorter overall survival in intensively treated patients according to multivariate analysis. In conclusion, high Jagged-1 surface level in leukemic cells is an independent favorable prognostic factor in patients with AML. To our knowledge, this is the first study evaluating the prognostic role of Notch-1-IC in AML blasts.
引用
收藏
页码:401 / 406
页数:6
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