Jagged-1: a new promising factor associated with favorable prognosis in patients with acute myeloid leukemia

被引：12

作者：

Czemerska, Magdalena ^{[1
]}

Pluta, Agnieszka ^{[1
]}

Szmigielska-Kaplon, Anna ^{[1
]}

Wawrzyniak, Ewa ^{[1
]}

Cebula-Obrzut, Barbara ^{[2
]}

Medra, Aleksandra ^{[2
]}

Smolewski, Piotr ^{[2
]}

Robak, Tadeusz ^{[1
]}

Wierzbowska, Agnieszka ^{[1
]}

机构：

[1] Med Univ Lodz, Dept Hematol, PL-93510 Lodz, Poland

[2] Med Univ Lodz, Dept Expt Hematol, PL-93510 Lodz, Poland

来源：

LEUKEMIA & LYMPHOMA | 2015年 / 56卷 / 02期

关键词：

Myeloid leukemias and dysplasias; prognostication; signaling therapies; HUMAN HOMOLOG; NOTCH; EXPRESSION; DIAGNOSIS; GROWTH; GENE;

D O I：

10.3109/10428194.2014.917638

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study Jagged-1 and Dll-1 surface expression as well as Notch-1 receptor intracellular domain (Notch-1-IC) expression were assessed by multi-color flow cytometry in leukemic blasts obtained from 88 patients with acute myeloid leukemia (AML). CD34+ peripheral blood stem cells (PBSCs) were used as a control. The median expression of Jagged-1 and Dll-1 was significantly higher in AML blasts than in PBSCs (p = 0.001 and p = 0.002, respectively). Higher expression of Notch-1-IC was detected in patients with poor-risk karyotype as compared to good-and intermediate-risk groups (p = 0.035). In our study, poor-risk cytogenetics and low (< median) expression of Jagged-1 were the only factors associated with significantly shorter overall survival in intensively treated patients according to multivariate analysis. In conclusion, high Jagged-1 surface level in leukemic cells is an independent favorable prognostic factor in patients with AML. To our knowledge, this is the first study evaluating the prognostic role of Notch-1-IC in AML blasts.

引用

页码：401 / 406

页数：6

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