2′-deoxy-2′(S)-ethinyl oligonucleotides:: A modification which selectively stabilizes oligoadenylate pairing to DNA complements

被引：18

作者：

Buff, R ^{[1
]}

Hunziker, J ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(98)00060-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oligonucleotides consisting of 2'-deoxy-2'(S)-ethinyl-thymidine, -uridine, and -adenosine have been prepared. Whereas the modified pyrimidine oligonucleotides uniformly lead to weaker pairing affinity with DNA and RNA complements, the corresponding adenine oligonucleotides show enhanced thermal stability in duplexes with complementary DNA and decreased stability with RNA. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：521 / 524

页数：4

共 16 条

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