Caenorhabditis elegans as a Model System for Duchenne Muscular Dystrophy

被引：5
作者：
Ellwood, Rebecca A. [1 ,2 ]
Piasecki, Mathew [1 ,2 ]
Szewczyk, Nathaniel J. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Nottingham, Med Res Council MRC Versus Arthrit, Ctr Musculoskeletal Ageing Res, Royal Derby Hosp, Derby DE22 3DT, England
[2] Nottingham Biomed Res Ctr, Natl Inst Hlth Res, Derby DE22 3DT, England
[3] Ohio Univ, Ohio Musculoskeletal & Neurol Inst, Athens, OH 45701 USA
[4] Ohio Univ, Dept Biomed Sci, Heritage Coll Osteopath Med, Athens, OH 45701 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 09期
基金：
英国生物技术与生命科学研究理事会;
关键词：
DMD; C; elegans; dystrophin; muscle; CARBONIC-ANHYDRASE-III; MUSCLE DEGENERATION; MDX MOUSE; ALPHA-CATULIN; BK CHANNEL; DYSTROBREVIN; GENE; INHIBITION; EXPRESSION; INTEGRITY;
D O I：
10.3390/ijms22094891
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The nematode worm Caenorhabditis elegans has been used extensively to enhance our understanding of the human neuromuscular disorder Duchenne Muscular Dystrophy (DMD). With new arising clinically relevant models, technologies and treatments, there is a need to reconcile the literature and collate the key findings associated with this model.
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页数：19
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