Heat shock protein 27 protects the heart against myocardial infarction

被引：116
作者：
Efthymiou, CA
Mocanu, MM
de Belleroche, J
Wells, DJ
Latchmann, DS
Yellon, DM
机构：
[1] UCL Hosp, Hatter Inst, London WC1E 6DB, England
[2] UCL Hosp, Ctr Cardiol, London WC1E 6DB, England
[3] Med Sch London, London WC1E 6DB, England
[4] Charing Cross Hosp, Imperial Coll London, Fac Med, Div Neurosci & Psychol Med, London W6 8RF, England
[5] UCL, Inst Child Hlth, London WC1N 1EH, England
来源：
BASIC RESEARCH IN CARDIOLOGY | 2004年 / 99卷 / 06期
关键词：
heat shock protein 27; reperfusion injury; infarct size; mouse;
D O I：
10.1007/s00395-004-0483-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Heat shock proteins (hsp) represent a group of chaperones which protects the cells against a diversity of stresses. It has been demonstrated that hsp27 is constitutively present in cells where it plays an important role in different cytoprotective processes which ultimately inhibit cell death. We investigated the response of the isolated perfused mouse heart over expressing hsp27 to the ischaemia/reperfusion injury using infarct size as an end point. Our results show for the first time that mice over expressing hsp27 (verified by Western blotting analysis) were found to be protected from lethal ischaemia/reperfusion injury compared to their negative littermates.
引用
收藏
页码：392 / 394
页数：3
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