Plasma levels of nitric oxide related amino acids in demented subjects with Down syndrome are related to neopterin concentrations

被引：17

作者：

Coppus, A. M. W. ^{[1
,2
]}

Fekkes, D. ^{[3
,5
]}

Verhoeven, W. M. A. ^{[4
,5
]}

Tuinier, S. ^{[4
]}

van Duijn, C. M. ^{[2
]}

机构：

[1] Ctr Intellectually Disabled, Dichterbij, Gennep, Netherlands

[2] Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands

[3] Erasmus Univ, Med Ctr, Dept Neurosci, Rotterdam, Netherlands

[4] Vincent van Gogh Inst Psychiat, Venray, Netherlands

[5] Erasmus Univ, Med Ctr, Dept Psychiat, Rotterdam, Netherlands

来源：

AMINO ACIDS | 2010年 / 38卷 / 03期

关键词：

Amino acids; Down syndrome; Neopterin; Nitric oxide; Branched chain amino acids; INDIVIDUALS; DIAGNOSIS;

D O I：

10.1007/s00726-009-0300-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Subjects with Down syndrome (DS) have abnormalities in virtually all aspects of the immune system and almost all will be affected with Alzheimer's disease (AD). It is thought that nitric oxide (NO) is involved in the pathophysiology of AD. In the present study, including a total of 401 elderly DS subjects, the spectrum of plasma amino acids and neopterin was investigated and related to development of AD. Concentrations of nearly all amino acids in DS subjects differed significantly from those of healthy controls. Neopterin was increased in DS subjects, especially in dementia. The production of NO as reflected by an increased citrulline/arginine ratio (Cit/Arg ratio) was enhanced during development of clinical dementia. Neopterin concentrations correlated to the Cit/Arg ratio only in the group of prevalent demented subjects (rho = 0.48, P = 0.006). The results of this study are suggestive for an increase in oxidative processes in DS subjects with AD.

引用

页码：923 / 928

页数：6

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