Incidence of and Risk Factors for Alzheimer's Disease and Mild Cognitive Impairment in Korean Elderly

被引：87

作者：

Bae, Jong Bin ^{[1
]}

Kim, You Joung ^{[2
]}

Han, Ji Won ^{[1
]}

Kim, Tae Hui ^{[3
]}

Park, Joon Hyuk ^{[4
]}

Lee, Seok Bum ^{[5
]}

Lee, Jung Jae ^{[5
]}

Jeong, Hyun Ghang ^{[9
]}

Kim, Jeong Lan ^{[6
]}

Jhoo, Jin Hyeong ^{[7
]}

Yoon, Jong Chul ^{[8
]}

Kim, Ki Woong ^{[1
,2
,10
,11
]}

机构：

[1] Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Songnam 463707, Gyeonggido, South Korea

[2] Natl Inst Dementia, Songnam, South Korea

[3] Wonju Severance Christian Hosp, Dept Psychiat, Wonju, South Korea

[4] Jeju Natl Univ Hosp, Dept Neuropsychiat, Cheju, South Korea

[5] Dankook Univ Hosp, Dept Psychiat, Cheonan, South Korea

[6] Chungnam Natl Univ Hosp, Dept Psychiat, Taejon, South Korea

[7] Kangwon Natl Univ Hosp, Dept Neuropsychiat, Chunchon, South Korea

[8] Kyunggi Prov Hosp Elderly, Dept Neuropsychiat, Yongin, South Korea

[9] Korea Univ, Guro Hosp, Dept Neuropsychiat, Seoul, South Korea

[10] Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea

[11] Seoul Natl Univ, Coll Med, Dept Brain & Cognit Sci, Seoul, South Korea

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2015年 / 39卷 / 1-2期

关键词：

Alzheimer's disease; Mild cognitive impairment; Epidemiology; Incidence; Risk factors; Korea; DEPRESSIVE SYMPTOMS; DEMENTIA; PREVALENCE; POPULATION; PROGRESSION; MORTALITY; DIAGNOSIS; LITERACY; VALIDITY; SUBTYPES;

D O I：

10.1159/000366555

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background/Aims: Knowledge of incidence rates and risk factors is essential for the development of strategies to treat patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Methods: A subpopulation of the Nationwide Survey on Dementia Epidemiology (460 Korean subjects aged years from 2 rural and 2 urban districts) was followed up for 3.5 years. The age-specific incidence was estimated and risk factors were identified. Results: The age-standardized incidence of AD and MCI was 7.9 and 28.1 cases per 1,000 person-years, respectively. MCI was associated with a 6-fold increased risk of AD. Depression was a risk factor for AD with MCI. Age, lack of formal education, illiteracy, rural residence, and marital status were associated with the risk of AD. Conclusion: Strategies to control modifiable risk factors should be implemented to decrease the incidence of AD. (C) 20140, Karger AG, Basel.

引用

页码：105 / 115

页数：11

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