Water-soluble self-assembled butadiyne-bridged bisporphyrin: A potential two-photon-absorbing photosensitizer for photodynamic therapy

被引：61

作者：

Dy, Joanne T. ^{[1
]}

Ogawa, Kazuya ^{[1
]}

Satake, Akiharu ^{[1
]}

Ishizumi, Atsushi ^{[1
]}

Kobuke, Yoshiaki ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Mat Sci, Nara 6300101, Japan

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2007年 / 13卷 / 12期

关键词：

photodynamic therapy; porphyrins; self-assembly; singlet oxygen; two-photon absorption;

D O I：

10.1002/chem.200601205

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have synthesized a novel, two-photon-absorbing photosensitizer for two-photon-absorption photodynamic therapy (2PA-PDT). The molecule is a butadiyne-bridged porphyrin dimer terminated with two water-soluble porphyrin monomers connected through Zn-imidazolyl self-assembly and covalently linked through olefin metathesis. It has an effective two-photon-absorption (2PA) cross-section value, sigma((2)), of 33 000 4600 GM with 5-ns pulses at 890 nm measured by using the open-aperture Z-scan technique. The compound was found to generate singlet oxygen, cytotoxic for tumor cells in photodynamic therapy (PDT), under 2PA conditions by conducting photobleaching experiments with anthracene-9,10-dipropionic acid sodium salt (ADPA).

引用

页码：3491 / 3500

页数：10

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