Epoxygenase eicosanoids: Synthesis of tetrahydrofuran-diol metabolites and their vasoactivity

被引：15

作者：

Falck, J. R.

Reddy, L. Manmohan

Byun, Kihwan

Campbell, William B.

Yi, Xiu-Yu

机构：

[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

[2] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 09期

关键词：

eicosanoids; epoxygenase; tetrahydrofuran; vasorelaxation; EETs;

D O I：

10.1016/j.bmcl.2007.01.096

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight members of a recently identified family of tetrahydrofuran-diols (THFDs), originating from epoxyeicosatrienoic acids (EETs), were prepared stereospecifically from D-(+)-glucose. The THFDs potently induced relaxation of pre-contracted bovine arteries. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2634 / 2638

页数：5

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