Roles of Aldolase Family Genes in Human Cancers and Diseases

被引：117
作者：
Chang, Yu-Chan [1 ]
Yang, Yi-Chieh [1 ,2 ]
Tien, Chia-Ping [3 ]
Yang, Chih-Jen [4 ,5 ,6 ]
Hsiao, Michael [1 ,7 ]
机构：
[1] Acad Sinica, Genom Res Ctr, Taipei, Taiwan
[2] Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan
[3] China Med Univ Hosp, Dept Family Med, Taichung, Taiwan
[4] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Div Pulm & Crit Care Med, Dept Internal Med, Kaohsiung, Taiwan
[5] Kaohsiung Med Univ, Sch Med, Coll Med, Kaohsiung, Taiwan
[6] Kaohsiung Med Univ, Kaohsiung Municipal Ta Tung Hosp, Dept Internal Med, Kaohsiung, Taiwan
[7] Kaohsiung Med Univ, Coll Med, Dept Biochem, Kaohsiung, Taiwan
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 08期
关键词：
GLYCOLYTIC-ENZYMES; POOR-PROGNOSIS; TUMOR MICROENVIRONMENT; CELL-PROLIFERATION; DIRECTLY INTERACTS; PANCREATIC-CANCER; EXPRESSION; METABOLISM; ALDOB; PATHWAY;
D O I：
10.1016/j.tem.2018.05.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human diseases and cancer types. However, non-enzymatic functions through protein-protein interactions or epigenetic modifications have been reported in recent years. Using high-throughput screening and -omics database integration, aldolase has been validated as an independent clinical prognostic marker of human cancers. Therefore, the aim of this review was to provide potential clinical value from in silico predictions and also summarize well-known signaling axes or phenotypes in various cancer types. Finally, we discuss the role of aldolase in the treatment of human diseases and cancers.
引用
收藏
页码：549 / 559
页数：11
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