Effect of thickness and PEG addition on the hydrolytic degradation of PLLA

被引:15
作者
Jonnalagadda, S
Robinson, DH [1 ]
机构
[1] Nebraska Med Ctr 986025, Coll Pharm, Dept Pharmaceut Sci, Omaha, NE 69198 USA
[2] USIP, Philadelphia Coll Pharm, Dept Pharmaceut Sci, Philadelphia, PA 19104 USA
关键词
polylactic acid; poly(ethylene glycol); biodegradable films; thermal analysis; autocatalytic degradation;
D O I
10.1163/1568562041959982
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
We previously demonstrated that cylindrical, biodegradable reservoirs fabricated with polylactide-polyethylene glycol (PLLA: PEG) films maintain constant permeability and enable zero-order drug delivery for up to 6 weeks in vitro. This research proposes that PEG not only enhances permeability but also extends of life of the device by allowing the escape of soluble degraded monomers thereby minimizing autocatalysis of PLLA. To test this hypothesis, cylindrical PLLA films with varying PEG concentrations (0-30%, w/w) and film-thickness (0.05-0.18 mm) were fabricated, and their degradation rate and thermal properties monitored for 23 weeks in vitro. The decrease in PLLA molecular weight for all films followed bi-exponential kinetics that fit the equation: y(t) = M(e(-K1t) + e(-K2t)), as was determined by a Pearson's coefficient > 0.95 for all films. The constant M was empirically determined to be equal to have the initial molecular weight of the degrading polymer. The value of K-1 was 5-60 orders of magnitude greater than K-2 and was attributed to the autocatalytic degradation based on its dependence on PEG concentration, film thickness, and correlation with the enthalpy change associated with the glass transition (DeltaC(p)). K-2 was attributed to simple hydrolytic cleavage of PLLA. The decrease in the value of K-1 with PEG concentration and thickness, and the correlation of K-1 with DeltaC(p), confirmed that the PLLA degradation can be controlled by incorporating PEG, as well as by modifying thickness.
引用
收藏
页码:1317 / 1326
页数:10
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