Pretreatment neutrophil-to-lymphocyte ratio predicts the prognosis in patients with metastatic prostate cancer

被引：32

作者：

Kawahara, Takashi ^{[1
,2
,3
]}

Yokomizo, Yumiko ^{[1
]}

Ito, Yusuke ^{[1
]}

Ito, Hiroki ^{[1
]}

Ishiguro, Hitoshi ^{[4
]}

Teranishi, Jun-ichi ^{[2
,3
]}

Makiyama, Kazuhide ^{[1
]}

Miyoshi, Yasuhide ^{[2
,3
]}

Miyamoto, Hiroshi ^{[5
,6
]}

Yao, Masahiro ^{[1
]}

Uemura, Hiroji ^{[2
,3
]}

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Urol, Yokohama, Kanagawa 232, Japan

[2] Yokohama City Med Ctr, Dept Urol, Yokohama, Kanagawa, Japan

[3] Yokohama City Med Ctr, Dept Renal Transplantat, Yokohama, Kanagawa, Japan

[4] Kanagawa Acad Sci & Technol, Photocatalyst Grp, Special Res Lab, Kawasaki, Kanagawa, Japan

[5] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Urol, Baltimore, MD 21205 USA

来源：

BMC CANCER | 2016年 / 16卷

关键词：

Prostate cancer; Biomarker; Neutrophil-to-lymphocyte ratio; Metastasis; CHEMOTHERAPY OUTCOMES; SURVIVAL; INFLAMMATION; RESECTION; ANTIGEN; RISK;

D O I：

10.1186/s12885-016-2134-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response in critical care patients, has been suggested as an independent prognostic factor for several solid malignancies. We investigated the utility of pretreatment NLR as a prognosticator in patients who presented with metastatic prostate cancer. Methods: We first investigated the correlation between NLR and prostate-specific antigen (PSA) levels in 1464 men who had both tests and were found to have prostate cancer on their biopsies at our institution from 1999 to 2015. We then assessed the relationship between pretreatment NLR and the prognosis in 48 patients who were diagnosed with prostate cancer metastasized to the lymph node and/or bone. Results: The NLR value was significantly elevated in men with higher PSA than in those with lower PSA (p < 0.001). In patients with metastatic prostate cancer, NLR (cut-off point of 3.37 determined by the AUROC curve) was correlated with both cancer-specific (p = 0.018) and overall (p = 0.008) survivals. Conclusions: Pretreatment NLR may function as a new biomarker that precisely predicts the prognosis in patients with metastatic prostate cancer.

引用

页数：6

共 31 条

[1] Usefulness of the Neutrophil-to-Lymphocyte Ratio in Predicting Short- and Long-Term Mortality in Breast Cancer Patients [J].