A pot-economical and green synthesis of novel (benzo[d]imidazo[2,1-b]thiazol-3-y1)-2H-chromen-2-one in ethanol PEG-600 under catalyst-free conditions

被引：32
作者：
Balwe, Sandip Gangadhar [1 ]
Lim, Kwon Taek [1 ]
Cho, Byung Gwon [1 ]
Jeong, Yeon Tae [1 ]
机构：
[1] Pukyong Natl Univ, Dept Image Sci & Engn, Busan 608737, South Korea
来源：
TETRAHEDRON | 2017年 / 73卷 / 25期
关键词：
Benzo[dlimidazo[2,1-b]thiazol-3-yI)-2H-chromen-2-one; Catalyst-free click chemistry; No column chromatography; Mild reaction conditions; One-pot synthesis; AQUEOUS WITTIG REACTIONS; N-PHOSPHONYL IMINES; CHEMOSELECTIVE SYNTHESIS; ORGANIC-SYNTHESIS; HIGHLY EFFICIENT; IN-VITRO; CHEMISTRY; SYSTEM; PEG; GUANYLHYDRAZONES;
D O I：
10.1016/j.tet.2017.05.047
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A catalyst-free, environmentally benign, and simple one-pot multi-component protocol has been developed for the efficient synthesis of novel (benzo[dlimidazo[2,1-bithiazol-3-y1)-2H-chromen-2-one derivatives in excellent yields using ethanol-PEG-600. This novel and green protocol have the advantages of shorter reaction times, high conversions, and follow the group-assisted-purification (GAP) chemistry process, which can avoid traditional purifications, chromatography and recrystallization. This is the first report for the synthesis of benzo[dlimidazo[2,1-blthiazol-3-yl)-2H-chromen-2-one. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3564 / 3570
页数：7
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