When metal-organic framework mediated smart drug delivery meets gastrointestinal cancers

被引：30

作者：

Hashemzadeh, Alireza ^{[1
]}

Drummen, Gregor P. C. ^{[2
]}

Avan, Amir ^{[3
]}

Darroudi, Majid ^{[4
]}

Khazaei, Majid ^{[1
,3
]}

Khajavian, Ruhollah ^{[5
]}

Rangrazi, Abdolrasoul ^{[6
]}

Mirzaei, Masoud ^{[5
]}

机构：

[1] Mashhad Univ Med Sci, Dept Med Physiol, Fac Med, Mashhad, Razavi Khorasan, Iran

[2] Bio & Nano Solut LAB3BIO, Bio Nanotechnol & Hepato Renal Pathobiol Programs, Bielefeld, Germany

[3] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran

[4] Mashhad Univ Med Sci, Nucl Med Res Ctr, Mashhad, Razavi Khorasan, Iran

[5] Ferdowsi Univ Mashhad, Dept Chem, Fac Sci, Mashhad 9177948974, Razavi Khorasan, Iran

[6] Mashhad Univ Med Sci, Dent Res Ctr, Mashhad, Razavi Khorasan, Iran

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2021年 / 9卷 / 19期

基金：

美国国家科学基金会;

关键词：

MESOPOROUS SILICA NANOPARTICLES; ONE-POT SYNTHESIS; HYDROPHILIC ANTICANCER DRUG; CELL LUNG-CANCER; PHOTODYNAMIC THERAPY; PHOTOTHERMAL THERAPY; COMBINATION THERAPY; CHECKPOINT BLOCKADE; MAGNETIC-RESONANCE; COLORECTAL-CANCER;

D O I：

10.1039/d1tb00155h

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Cancers of the gastrointestinal tract constitute one of the most common cancer types worldwide and a similar to 58% increase in the global number of cases has been estimated by IARC for the next twenty years. Recent advances in drug delivery technologies have attracted scientific interest for developing and utilizing efficient therapeutic systems. The present review focuses on the use of nanoscale MOFs (Nano-MOFs) as carriers for drug delivery and imaging purposes. In pursuit of significant improvements to current gastrointestinal cancer chemotherapy regimens, systems that allow multiple concomitant therapeutic options (polytherapy) and controlled release are highly desirable. In this sense, MOF-based nanotherapeutics represent a significant step towards achieving this goal. Here, the current state-of-the-art of interdisciplinary research and novel developments into MOF-based gastrointestinal cancer therapy are highlighted and reviewed.

引用

页码：3967 / 3982

页数：16

共 314 条

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