Pharmacokinetic Changes during Pregnancy According to Genetic Variants: a Prospective Study in HIV-Infected Patients Receiving Atazanavir-Ritonavir

被引：3
作者：
Foca, Emanuele [1 ,2 ]
Calcagno, Andrea [3 ]
Bonito, Andrea [1 ,2 ]
Cusato, Jessica [3 ]
Domenighini, Elisabetta [1 ,2 ]
D'Avolio, Antonio [3 ]
Roldan, Eugenia Quiros [1 ,2 ]
Trentini, Laura [3 ]
Castelnuovo, Filippo [1 ,2 ]
Di Perri, Giovanni [3 ]
Casteill, Francesco [1 ,2 ]
Bonora, Stefano [3 ]
机构：
[1] Univ Brescia, Dept Clin & Expt Sci, Unit Infect & Trop Dis, Brescia, Italy
[2] Spedali Civili Gen Hosp, Brescia, Italy
[3] Univ Torino, Dept Med Sci, Unit Infect Dis, Turin, Italy
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 07期
关键词：
HIV; antiretroviral agents; antiviral pharmacology; INTRACELLULAR ACCUMULATION; PLASMA-CONCENTRATIONS; UNBOOSTED ATAZANAVIR; POLYMORPHISMS; OATP1B1; LOPINAVIR/RITONAVIR; ASSOCIATION; LOPINAVIR; TRANSPORT; DRUGS;
D O I：
10.1128/AAC.00309-18
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Atazanavir-ritonavir concentrations change over time during pregnancy in HIV-positive patients; the impact of genetic variants is unknown. Twenty patients were enrolled in this study; plasma and intracellular concentrations of antiretrovirals were measured, in addition to single-nucleotide polymorphisms in transport-related genes. Linear logistic regression showed that genetic variants in organic-aniontransporter-1B1- and pregnane-X-receptor-encoding genes affected third-trimester atazanavir exposure. In this prospective study, genetic variants partially explained the observed interpatient variability in third-trimester exposure to antiretrovirals.
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页数：5
相关论文
共 26 条
[1]   Intracellular Pharmacokinetics of Antiretroviral Drugs in HIV-Infected Patients, and their Correlation with Drug Action [J].
Bazzoli, Caroline ;
Jullien, Vincent ;
Le Tiec, Clotilde ;
Rey, Elisabeth ;
Mentre, France ;
Taburet, Anne-Marie .
CLINICAL PHARMACOKINETICS, 2010, 49 (01) :17-45
[2]   Virological, intracellular and plasma pharmacological parameters predicting response to lopinavir/ritonavir (KALEPHAR Study) [J].
Breilh, D ;
Pellegrin, I ;
Rouzés, A ;
Berthoin, K ;
Xuereb, F ;
Budzinski, H ;
Munck, M ;
Fleury, HJA ;
Saux, MC ;
Pellegrin, JL .
AIDS, 2004, 18 (09) :1305-1310
[3]   Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) [J].
Chang, TKH ;
Waxman, DJ .
DRUG METABOLISM REVIEWS, 2006, 38 (1-2) :51-73
[4]   Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice [J].
Chen, Shujuan ;
Yueh, Mei-Fei ;
Evans, Ronald M. ;
Tukey, Robert H. .
HEPATOLOGY, 2012, 56 (02) :658-667
[5]   Population pharmacokinetics of atazanavir in patients with human immunodeficiency virus infection [J].
Colombo, Sara ;
Buclin, Thierry ;
Cavassini, Matthias ;
Decosterd, Laurent A. ;
Telenti, Amalio ;
Biollaz, Jerome ;
Csajka, Chantal .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (11) :3801-3808
[6]  
Crommentuyn KML, 2004, ANTIVIR THER, V9, P779
[7]   Intracellular accumulation of atazanavir/ritonavir according to plasma concentrations and OATP1B1, ABCB1 and PXR genetic polymorphisms [J].
D'Avolio, Antonio ;
Carcieri, Chiara ;
Cusato, Jessica ;
Simiele, Marco ;
Calcagno, Andrea ;
Allegra, Sarah ;
Sciandra, Mauro ;
Trentini, Laura ;
Di Perri, Giovanni ;
Bonora, Stefano .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 69 (11) :3061-3066
[8]   Clinical aspects of the MDRI (ABCB1) gene polymorphism [J].
Eichelbaum, M ;
Fromm, MF ;
Schwab, M .
THERAPEUTIC DRUG MONITORING, 2004, 26 (02) :180-185
[9]   Atazanavir intracellular concentrations remain stable during pregnancy in HIV-infected patients [J].
Foca, Emanuele ;
Calcagno, Andrea ;
Bonito, Andrea ;
Simiele, Marco ;
Domenighini, Elisabetta ;
D'Avolio, Antonio ;
Roldan, Eugenia Quiros ;
Trentini, Laura ;
Casari, Salvatore ;
Di Perri, Giovanni ;
Castelli, Francesco ;
Bonora, Stefano .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2017, 72 (11) :3163-3166
[10]   Unboosted atazanavir for treatment of HIV infection: Rationale and recommendations for use [J].
Emanuele Focà ;
Diego Ripamonti ;
Davide Motta ;
Carlo Torti .
Drugs, 2012, 72 (9) :1161-1173
123