An Efficient One-Pot Synthesis and Anticancer Activity of 4'-Substituted Flavonoids

被引：6
|
作者：
Wang, X. [1 ]
Liu, J. [2 ]
Zhang, Y. [1 ]
机构：
[1] Shangluo Univ, Coll Biol Pharm & Food Engn, Shangluo 726000, Peoples R China
[2] Northwest Univ, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Sch Life Sci, Xian 710069, Shaanxi, Peoples R China
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2018年 / 88卷 / 05期
基金：
中国国家自然科学基金;
关键词：
flavone derivatives; synthesis; Baker-Venkataraman; antiproliferative activity; DERIVATIVES; FLAVANONES; CHALCONES;
D O I：
10.1134/S1070363218050328
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A number of 4'-substituted (R = H, Me, Cl, F) flavone derivatives is synthesized from 2-hydroxyacetophenones using the modified Baker-Venkataraman reaction. Compound [3-(4-fluorobenzoyl)-5- hydroxy-4'-fluoroflavone] was synthesized for the first time with the yield of 12%. Antiproliferative assays indicate that the synthesized flavones with F substituent at the 4' position demonstrate higher activity than the other flavone derivatives, particularly against HeLa and MCF-7 with the IC50 9.5 and 2.7 mu M, respectively.
引用
收藏
页码：1036 / 1041
页数：6
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