Induced Pluripotent Stem Cell-Derived Mesenchymal Stem/Stromal Cells: A Leap Toward Personalized Therapies for Cancer

被引：6

作者：

Whitt, Jason ^{[1
]}

Vallabhaneni, Krishna C. ^{[1
]}

Penfornis, Patrice ^{[1
]}

Pochampally, Radhika ^{[1
,2
]}

机构：

[1] Univ Mississippi, Med Ctr, Inst Canc, Jackson, MS 39216 USA

[2] Univ Mississippi, Med Ctr, Dept Biochem, Jackson, MS 39216 USA

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2016年 / 11卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Cancer; cell therapy; iPSCs; MSCs; precision medicine; BONE-MARROW; STROMAL CELLS; APC MUTATIONS; DIFFERENTIATION; INDUCTION; DELIVERY; REPAIR; GENE; TRANSPLANTATION; METASTASES;

D O I：

10.2174/1574888X10666151001114321

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mesenchymal Stem/stromal cell (MSCs) transplantation procedures have been used since the 1960's to treat leukemia and other diseases, but due to the risks involved only patients with life threatening illnesses were typically subjected to the transplantation procedure until the last decade. Recent advancements in transplantation techniques have made it more feasible to use it for non-life-threatening diseases. However, the potential uses for stem cells are still limited by their rarity, and, in the case of allogeneic transplants, graft-vs.-host complications. An evolving alternative to conventional stem cell therapies is induced pluripotent stem-cell derived mesenchymal stem/stromal cells (iPSC-MSCs), which have a multi-lineage potential comparable to conventionally acquired MSCs with the added benefit of being less immunoreactive. However there are still many hurdles left to be overcome before they can be used regularly for personalized therapies. This review will focus on recent advancements that have been made regarding the role MSCs play in tumor development and the potential uses iPSC-MSCs may have in future cancer treatment.

引用

页码：141 / 148

页数：8

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