Homologation of polyamines in the synthesis of lipo-spermine conjugates and related lipoplexes

被引：47

作者：

Geall, AJ ^{[1
]}

Blagbrough, IS ^{[1
]}

机构：

[1] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 5-6期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(97)10543-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polyamine amides are useful in gene delivery as synthetic (non-viral) vectors or mimics of polycationic histones. The application of a homologation strategy, based upon reductive alkylation, allows unsymmetrical polyamine amides to be prepared in good yield. The interaction of this polyamine amide with calf thymus DNA was demonstrated in an ethidium bromide fluorescence quenching assay. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：443 / 446

页数：4

共 27 条

[1] SYNTHETIC GENE-TRANSFER VECTORS [J].

BEHR, JP .

ACCOUNTS OF CHEMICAL RESEARCH, 1993, 26 (05) :274-278

[2] EFFICIENT GENE-TRANSFER INTO MAMMALIAN PRIMARY ENDOCRINE-CELLS WITH LIPOPOLYAMINE-COATED DNA [J].

BEHR, JP ;

DEMENEIX, B ;

LOEFFLER, JP ;

MUTUL, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (18) :6982-6986

[3] Practical synthesis of unsymmetrical polyamine amides [J].

Blagbrough, IS ;

Geall, AJ .

TETRAHEDRON LETTERS, 1998, 39 (5-6) :439-442

[4]

BLAGBROUGH IS, 1997, PHARM SCI, V3, P223

[5] DNA condensation [J].

Bloomfield, VA .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1996, 6 (03) :334-341

[6] POTENTIAL ANTI-TUMOR AGENTS .28. DEOXYRIBONUCLEIC-ACID POLYINTERCALATING AGENTS [J].

CAIN, BF ;

BAGULEY, BC ;

DENNY, WA .

JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (07) :658-668

[7] TRANSFER OF GENES TO HUMANS - EARLY LESSONS AND OBSTACLES TO SUCCESS [J].

CRYSTAL, RG .

SCIENCE, 1995, 270 (5235) :404-410

[8]

FELGNER PL, 1997, SCI AM, V276, P86

[9] MODE OF FORMATION AND STRUCTURAL FEATURES OF DNA CATIONIC LIPOSOME COMPLEXES USED FOR TRANSFECTION [J].

GERSHON, H ;

GHIRLANDO, R ;

GUTTMAN, SB ;

MINSKY, A .

BIOCHEMISTRY, 1993, 32 (28) :7143-7151

[10] STRUCTURAL EFFECTS IN NOVEL STEROIDAL POLYAMINE-DNA BINDING [J].

HSIEH, HP ;

MULLER, JG ;

BURROWS, CJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (26) :12077-12078

← 1 2 3 →