Homologation of polyamines in the synthesis of lipo-spermine conjugates and related lipoplexes

被引:47
作者
Geall, AJ [1 ]
Blagbrough, IS [1 ]
机构
[1] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England
基金
英国工程与自然科学研究理事会;
关键词
D O I
10.1016/S0040-4039(97)10543-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Polyamine amides are useful in gene delivery as synthetic (non-viral) vectors or mimics of polycationic histones. The application of a homologation strategy, based upon reductive alkylation, allows unsymmetrical polyamine amides to be prepared in good yield. The interaction of this polyamine amide with calf thymus DNA was demonstrated in an ethidium bromide fluorescence quenching assay. (C) 1997 Elsevier Science Ltd. All rights reserved.
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页码:443 / 446
页数:4
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