Emerging Concepts in Treating Cartilage, Osteochondral Defects, and Osteoarthritis of the Knee and Ankle

被引：15

作者：

Pereira, Helder ^{[1
,2
,3
,4
,5
]}

Cengiz, Ibrahim Fatih ^{[3
,4
]}

Vilela, Carlos ^{[3
,4
]}

Ripoll, Pedro L. ^{[2
,5
]}

Espregueira-Mendes, Joao ^{[3
,4
,6
,7
,8
]}

Oliveira, J. Miguel ^{[3
,4
,9
]}

Reis, Rui L. ^{[3
,4
,9
]}

van Dijk, C. Niek ^{[5
,10
,11
]}

机构：

[1] Ctr Hosp Povoa Varzim, Orthoped Dept, Vila Do Conde, Portugal

[2] Int Ctr Sports Traumatol Ave, Taipas, Portugal

[3] Univ Minho, European Inst Excellence Tissue Engn & Regenerat, 3Bs Res Grp Biomat Biodegradables & Biomimet, Avepk,Parque Ciencia & Tecnol, Barco, Guimaraes, Portugal

[4] ICVS 3Bs PT Govt Associate Lab, Braga, Guimaraes, Portugal

[5] Murcia Madrid FIFA Med Ctr Excellence, Ripoll & De Prado Sports Clin, Madrid, Spain

[6] FIFA Med Ctr Excellence, Espregueira Mendes Sports Ctr, Clin Dragao, Porto, Portugal

[7] Dom Henr Res Ctr, Porto, Portugal

[8] Univ Minho, Orthoped Dept, Braga, Portugal

[9] Univ Minho, Discoveries Ctr Regenerat & Precis Med, Guimaraes, Portugal

[10] Univ Amsterdam, Acad Med Ctr, Amsterdam Movement Sci, Dept Orthopaed Surg, Amsterdam, Netherlands

[11] Univ Amsterdam, Acad Med Ctr, Amsterdam Movement Sci, Acad Ctr Evidence Based Sports Med, Amsterdam, Netherlands

来源：

OSTEOCHONDRAL TISSUE ENGINEERING: CHALLENGES, CURRENT STRATEGIES, AND TECHNOLOGICAL ADVANCES | 2018年 / 1059卷

关键词：

Surgery; Autologous osteochondral transplantation; Bone marrow stimulation; Congruency; Alignment; Tissue engineering and regenerative medicine; MESENCHYMAL STEM-CELLS; AUTOLOGOUS CHONDROCYTE IMPLANTATION; BETA-TRICALCIUM PHOSPHATE; FOOTBALL SOCCER PLAYERS; PLATELET-RICH PLASMA; ARTICULAR-CARTILAGE; CHONDRAL DEFECTS; ADIPOSE-TISSUE; BASIC SCIENCE; FOLLOW-UP;

D O I：

10.1007/978-3-319-76735-2_2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The management and treatment of cartilage lesions, osteochondral defects, and osteoarthritis remain a challenge in orthopedics. Moreover, these entities have different behaviors in different joints, such as the knee and the ankle, which have inherent differences in function, biology, and biomechanics. There has been a huge development on the conservative treatment (new technologies including orthobiologics) as well as on the surgical approach. Some surgical development upraises from technical improvements including advanced arthroscopic techniques but also from increased knowledge arriving from basic science research and tissue engineering and regenerative medicine approaches. This work addresses the state of the art concerning basic science comparing the knee and ankle as well as current options for treatment. Furthermore, the most promising research developments promising new options for the future are discussed.

引用

页码：25 / 62

页数：38

共 237 条

[1] Mobilization of bone marrow-derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration [J].