Adoptive T Cell Immunotherapy for Treatment of Ganciclovir-Resistant Cytomegalovirus Disease in a Renal Transplant Recipient

被引：54
|
作者：
Macesic, N. [1 ]
Langsford, D. [2 ]
Nicholls, K. [2 ]
Hughes, P. [2 ]
Gottlieb, D. J. [3 ]
Clancy, L. [4 ]
Blyth, E. [3 ,5 ]
Micklethwaite, K. [4 ]
Withers, B. [3 ]
Majumdar, S. [1 ]
Fleming, S. [6 ]
Sasadeusz, J. [1 ]
机构：
[1] Royal Melbourne Hosp, Victorian Infect Dis Serv, Parkville, Vic 3050, Australia
[2] Royal Melbourne Hosp, Dept Nephrol, Parkville, Vic 3050, Australia
[3] Univ Sydney, Fac Med, Westmead Hosp, Sydney, NSW 2006, Australia
[4] Westmead Hosp, Sydney Cellular Therapies Lab, Sydney, NSW, Australia
[5] Westmead Hosp, Westmead Millennium Inst, Sydney, NSW, Australia
[6] Royal Melbourne Hosp, Dept Clin Haematol, Parkville, Vic 3050, Australia
来源：
AMERICAN JOURNAL OF TRANSPLANTATION | 2015年 / 15卷 / 03期
关键词：
ORGAN TRANSPLANT; IMMUNITY; THERAPY; MULTICENTER;
D O I：
10.1111/ajt.13023
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Cytomegalovirus (CMV) is a significant cause of morbidity, mortality and graft loss in solid organ transplantation (SOT). Treatment options for ganciclovir-resistant CMV are limited. We describe a case of ganciclovir-resistant CMV disease in a renal transplant recipient manifested by thrombotic microangiopathy-associated glomerulopathy. Adoptive T cell immunotherapy using CMV-specific T cells from a donor bank was used as salvage therapy. This report is a proof-of-concept of the clinical and logistical feasibility of this therapy in SOT recipients. Adoptive T cell immunotherapy using cytomegalovirus-specific T cells from a donor bank is used as salvage therapy in a case of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient.
引用
收藏
页码：827 / 832
页数：6
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