Adoptive T Cell Immunotherapy for Treatment of Ganciclovir-Resistant Cytomegalovirus Disease in a Renal Transplant Recipient

被引：54

作者：

Macesic, N. ^{[1
]}

Langsford, D. ^{[2
]}

Nicholls, K. ^{[2
]}

Hughes, P. ^{[2
]}

Gottlieb, D. J. ^{[3
]}

Clancy, L. ^{[4
]}

Blyth, E. ^{[3
,5
]}

Micklethwaite, K. ^{[4
]}

Withers, B. ^{[3
]}

Majumdar, S. ^{[1
]}

Fleming, S. ^{[6
]}

Sasadeusz, J. ^{[1
]}

机构：

[1] Royal Melbourne Hosp, Victorian Infect Dis Serv, Parkville, Vic 3050, Australia

[2] Royal Melbourne Hosp, Dept Nephrol, Parkville, Vic 3050, Australia

[3] Univ Sydney, Fac Med, Westmead Hosp, Sydney, NSW 2006, Australia

[4] Westmead Hosp, Sydney Cellular Therapies Lab, Sydney, NSW, Australia

[5] Westmead Hosp, Westmead Millennium Inst, Sydney, NSW, Australia

[6] Royal Melbourne Hosp, Dept Clin Haematol, Parkville, Vic 3050, Australia

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2015年 / 15卷 / 03期

关键词：

ORGAN TRANSPLANT; IMMUNITY; THERAPY; MULTICENTER;

D O I：

10.1111/ajt.13023

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Cytomegalovirus (CMV) is a significant cause of morbidity, mortality and graft loss in solid organ transplantation (SOT). Treatment options for ganciclovir-resistant CMV are limited. We describe a case of ganciclovir-resistant CMV disease in a renal transplant recipient manifested by thrombotic microangiopathy-associated glomerulopathy. Adoptive T cell immunotherapy using CMV-specific T cells from a donor bank was used as salvage therapy. This report is a proof-of-concept of the clinical and logistical feasibility of this therapy in SOT recipients. Adoptive T cell immunotherapy using cytomegalovirus-specific T cells from a donor bank is used as salvage therapy in a case of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient.

引用

页码：827 / 832

页数：6

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