The role of epithelial-mesenchymal transition in oral squamous cell carcinoma and oral submucous fibrosis

被引：44
作者：
Hu Yanjia
Jian Xinchun
机构：
[1] Xiang Ya Hospital, Central South University
来源：
CLINICA CHIMICA ACTA | 2007年 / 383卷 / 1-2期
基金：
中国国家自然科学基金;
关键词：
epithelial-mesenchymal transition (EMT); oral submucous fibrosis (OSF); transforming growth factor-beta; (TGF-beta); pathway;
D O I：
10.1016/j.cca.2007.04.014
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Epithelial-mesenchymal transition (EMT) is an indispensable mechanism during morphogenesis. Interest and research in EMT are currently at a high level due to its important role in cancer and fibrosis. Emerging evidence suggests that EMT is also a crucial event in oral squamous cell carcinoma (OSCC). Oral submucous fibrosis (OSF) is a chronic debilitating disease and a premalignant condition of the oral cavity. It is characterized by a generalized submucosal fibrosis. The pathogenesis of the disease is not well established. Epidemiological evidence strongly indicates an association between the betel quid (BQ) chewing habit and OSF. In a simplistic view, OSF represents a failed wound-healing process of the oral mucosa after chronic, sustained injury. This review highlights the signaling pathways involved in EMT, recent advances in the study of EMT in OSCC, and summarizes the evidence supporting a role for EMT in the pathogenesis of OSF. Crown Copyright (C) 2007 Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：51 / 56
页数：6
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