The GIGYF2 variants are not associated with Parkinson's disease in the mainland Chinese population

被引：7

作者：

Cao, L. ^{[1
,2
]}

Zhang, T. ^{[1
,2
]}

Zheng, L. ^{[1
,2
]}

Wang, Y. ^{[1
,2
]}

Wang, G. ^{[1
,2
]}

Zhang, J. ^{[1
,2
]}

Fei, Q. Z. ^{[1
,2
]}

Cui, P. J. ^{[1
,2
]}

Wang, X. J. ^{[1
,2
]}

Ma, J. F. ^{[1
,2
]}

Xiao, Q. ^{[1
,2
]}

Chen, S. D. ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Dept Neurol, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Inst Neurol, Shanghai 200025, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Neurodegenerat Dis, Shanghai 200025, Peoples R China

来源：

PARKINSONISM & RELATED DISORDERS | 2010年 / 16卷 / 04期

关键词：

GIGYF2; Parkinson's disease; Chinese population; MUTATIONS; ASN56SER; LINKAGE; GENE;

D O I：

10.1016/j.parkreldis.2009.11.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In order to determine the prevalence of GIGYF2 (Grb10-Interacting GYF Protein 2) variants in the Chinese population and to better understand the association between GIGYF2 and Parkinson's disease (PD), we conducted the genetic screening of GIGYF2 in the Chinese population. Twelve exonic variants were identified in 52 familial PD probands and 56 healthy controls. Non-synonymous point variants (Thr25Ala, Asn457Th and Pro460Th) were analyzed in 510 PD patients and 481 healthy controls of Chinese Han ethnicity. The insertion and deletion variants in Exon 25 (Ins Q 1212, Ins QQ 1217, Del Q 1210, Del Q 1216 and Del PPQ1217_1219) are not related to the onset of familial PD. Our data indicate the GIGYF2 variants are not associated with PD in the mainland Chinese Population. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：294 / 297

页数：4

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