Core-shell alginate-ghatti gum modified montmorillonite composite matrices for stomach-specific flurbiprofen delivery

被引：39
作者：
Bera, Hriday [1 ,2 ]
Ippagunta, Sohitha Reddy [2 ]
Kumar, Sanoj [2 ]
Vangala, Pavani [2 ]
机构：
[1] AIMST Univ, Fac Pharm, Semeling 08100, Kedah, Malaysia
[2] Gokaraju Rangaraju Coll Pharm, Hyderabad 500090, Andhra Pradesh, India
来源：
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 76卷
关键词：
Sodium alginate; Ghatti gum; Arabic gum; Clay; Intragastric drug delivery; IN-VITRO RELEASE; CHITOSAN MICROSPHERES; SYSTEM INTERCALATION; DRUG-RELEASE; BEADS; GEL; NANOCOMPOSITE; ENTRAPMENT; ADSORPTION; SCAFFOLD;
D O I：
10.1016/j.msec.2017.03.074
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Novel alginate-arabic gum (AG) gel membrane coated alginate-ghatti gum (GG) modified montmorillonite (MMT) composite matrices were developed for intragastric flurbiprofen (FLU) delivery by combining floating and mucoadhesion mechanisms. The clay-biopolymer composite matrices containing FLU as core were accomplished by ionic-gelation technique. Effects of polymer-blend (alginate:GG) ratios and crosslinker (CaCl2) concentrations on drug entrapment efficiency (DEE, %) and cumulative drug release after 8 h (Q(8h), %) were studied to optimize the core matrices by a 32 factorial design. The optimized matrices (F-O) demonstrated DEE of 91.69 +/- 1.43% and Q(8h) of 74.96 +/- 1.56% with minimum errors in prediction. The alginate-AG gel membrane enveloped optimized matrices (F-O, coated) exhibited superior buoyancy, better ex vivo mucoadhesion and slower drug release rate. The drug release profile of FLU-loaded uncoated and coated optimized matrices was best fitted in Korsmeyer-Peppas model with anomalous diffusion and case-II transport driven mechanism, respectively. The uncoated and coated matrices containing FLU were also characterized for drug-excipients compatibility, drug crystallinity, thermal behaviour and surface morphology. Thus, the newly developed alginate AG gel membrane coated alginate-GG modified MMT composite matrices are appropriate for intragastric delivery of FLU over an extended period of time with improved therapeutic benefits. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：715 / 726
页数：12
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