Fetal Growth Restriction Caused by Sexual Transmission of Zika Virus in Mice

被引：37

作者：

Uraki, Ryuta ^{[1
]}

Jurado, Kellie Ann ^{[2
]}

Hwang, Jesse ^{[1
]}

Szigeti-Buck, Klara ^{[3
]}

Horvath, Tamas L. ^{[3
]}

Iwasaki, Akiko ^{[2
,4
]}

Fikrig, Erol ^{[1
,4
]}

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, Sect Infect Dis, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT USA

[3] Yale Univ, Sch Med, Dept Comparat Med, Program Integrat Cell Signaling & Neurobiol Metab, New Haven, CT USA

[4] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2017年 / 215卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Zika virus; sexual transmission; fetal growth abnormalities; electron microscopy; MOUSE MODEL; INFECTION; SEMEN; LEADS;

D O I：

10.1093/infdis/jix204

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Zika virus (ZIKV) can be transmitted by mosquito bite or sexual contact. Using mice that lack the type I interferon receptor, we examined sexual transmission of ZIKV. Electron microscopy analyses showed association of virions with developing sperm within testes as well as with mature sperm within epididymis. When ZIKV-infected male mice were mated with naive female mice, the weight of fetuses at embryonic day 18.5 was significantly reduced compared with the control group. Additionally, we found ocular deformities in a minority of the fetuses. These results suggest that ZIKV causes fetal abnormalities after female mating with an infected male.

引用

页码：1720 / 1724

页数：5

共 15 条

[1] Cytoplasmic droplets: the good, the bad or just confusing? [J].

Cooper, TG .

HUMAN REPRODUCTION, 2005, 20 (01) :9-11

[2] Evidence of Sexual Transmission of Zika Virus [J].

D'Ortenzio, Eric ;

Matheron, Sophie ;

Yazdanpanah, Yazdan .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (22) :2195-2198

[3] Frequent Zika Virus Sexual Transmission and Prolonged Viral RNA Shedding in an Immunodeficient Mouse Model [J].

Duggal, Nisha K. ;

Ritter, Jana M. ;

Pestorius, Samuel E. ;

Zaki, Sherif R. ;

Davis, Brent S. ;

Chang, Gwong-Jen J. ;

Bowen, Richard A. ;

Brault, Aaron C. .

CELL REPORTS, 2017, 18 (07) :1751-1760

[4] Zika virus infection damages the testes in mice [J].

Govero, Jennifer ;

Esakky, Prabagaran ;

Scheaffer, Suzanne M. ;

Fernandez, Estefania ;

Drury, Andrea ;

Platt, Derek J. ;

Gorman, Matthew J. ;

Richner, Justin M. ;

Caine, Elizabeth A. ;

Salazar, Vanessa ;

Moley, Kelle H. ;

Diamond, Michael S. .

NATURE, 2016, 540 (7633) :438-+

[5] Transmission of Zika Virus Through Sexual Contact with Travelers to Areas of Ongoing Transmission - Continental United States, 2016 [J].

Hills, Susan L. ;

Russell, Kate ;

Hennessey, Morgan ;

Williams, Charnetta ;

Oster, Alexandra M. ;

Fischer, Marc ;

Mead, Paul .

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2016, 65 (08) :215-216

[6] Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication [J].

Khan, Shahzada ;

Woodruff, Erik M. ;

Trapecar, Martin ;

Fontaine, Krystal A. ;

Ezaki, Ashley ;

Borbet, Timothy C. ;

Ott, Melanie ;

Sanjabi, Shomyseh .

JOURNAL OF EXPERIMENTAL MEDICINE, 2016, 213 (13) :2913-2929

[7] Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice [J].

Ma, Wenqiang ;

Li, Shihua ;

Ma, Shuoqian ;

Jia, Lina ;

Zhang, Fuchun ;

Zhang, Yong ;

Zhang, Jingyuan ;

Wong, Gary ;

Zhang, Shanshan ;

Lu, Xuancheng ;

Liu, Mei ;

Yan, Jinghua ;

Li, Wei ;

Qin, Chuan ;

Han, Daishu ;

Qin, Chengfeng ;

Wang, Na ;

Li, Xiangdong ;

Gao, George Fu .

CELL, 2016, 167 (06) :1511-+

[8] Zika virus in semen and spermatozoa [J].

Mansuy, Jean Michel ;

Suberbielle, Elsa ;

Chapuy-Regaud, Sabine ;

Mengelle, Catherine ;

Bujan, Louis ;

Marchou, Bruno ;

Delobel, Pierre ;

Gonzalez-Dunia, Daniel ;

Malnou, Cecile E. ;

Izopet, Jacques ;

Martin-Blondel, Guillaume .

LANCET INFECTIOUS DISEASES, 2016, 16 (10) :1106-1107

[9] Semen-derived amyloid fibrils drastically enhance HIV infection [J].

Muench, Jan ;

Ruecker, Elke ;

Staendker, Ludger ;

Adermann, Knut ;

Goffinet, Christine ;

Schindler, Michael ;

Wildum, Steffen ;

Chinnadurai, Raghavan ;

Rajan, Devi ;

Specht, Anke ;

Gimenez-Gallego, Guillermo ;

Cuevas Sanchez, Pedro ;

Fowler, Douglas M. ;

Koulov, Atanas ;

Kelly, Jeffery W. ;

Mothes, Walther ;

Grivel, Jean-Charles ;

Margolis, Leonid ;

Keppler, Oliver T. ;

Forssmann, Wolf-Georg ;

Kirchhoff, Frank .

CELL, 2007, 131 (06) :1059-1071

[10] Persistent detection of Zika virus RNA in semen for six months after symptom onset in a traveller returning from Haiti to Italy, February 2016 [J].

Nicastri, E. ;

Castilletti, C. ;

Liuzzi, G. ;

Iannetta, M. ;

Capobianchi, M. R. ;

Ippolito, G. .

EUROSURVEILLANCE, 2016, 21 (32) :6-9

← 1 2 →