Histiocytosis with mixed cell populations

被引：10

作者：

Martin, Jose M. ^{[1
,3
]}

Jorda, Esperanza ^{[1
,3
]}

Martin-Gorgojo, Alejandro ^{[1
]}

Beteta, Gerardo ^{[1
]}

Monteagudo, Carlos ^{[2
,3
]}

机构：

[1] Hosp Clin Univ, Dept Dermatol, Valencia, Spain

[2] Hosp Clin Univ, Dept Pathol, Valencia, Spain

[3] Univ Valencia, Sch Med, Valencia, Spain

来源：

JOURNAL OF CUTANEOUS PATHOLOGY | 2016年 / 43卷 / 05期

关键词：

histiocytosis; histopathology; indeterminate cell histiocytosis; juvenile xantogranuloma; langerhans cell histiocytosis; JUVENILE XANTHOGRANULOMA; LANGERHANS; DISEASE;

D O I：

10.1111/cup.12687

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Langerhans cell histiocytosis (LCH) and juvenile xanthogranuloma (JXG) are thought to originate from a common stem cell precursor, with divergent differentiation under different microenvironmental conditions. We describe an exceptional case of multiple cutaneous lesions in a 10-year-old boy, in which the coexistence of both LCH and JXG cell populations is found in every single lesion. The presence of Birbeck granules and CD207 (langerin) immunostaining in the LCH component would argue against the diagnosis of indeterminate cell histiocytosis (ICH). This unique case gives additional support to the hypothesis of a potentially common histogenesis for LCH and JXG.

引用

页码：456 / 460

页数：5

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