GALA, a database for genomic sequence alignments and annotations

被引：35
|
作者：
Giardine, B
Elnitski, L
Riemer, C
Makalowska, L
Schwartz, S
Miller, W
Hardison, RC [1 ]
机构：
[1] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA
[2] Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA
[3] Penn State Univ, Dept Biol, University Pk, PA 16802 USA
[4] Penn State Univ, Huck Inst Life Sci, University Pk, PA 16802 USA
来源：
GENOME RESEARCH | 2003年 / 13卷 / 04期
关键词：
D O I：
10.1101/gr.603103
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have developed a relational database to contain whole genome sequence alignments between human and mouse with extensive annotations of the human sequence. Complex queries are supported on recorded features, both directly and on proximity among them. Searches can reveal a wide variety of relationships, such as finding all genes expressed in a designated tissue that have a highly conserved noncoding sequence S' to the start site. Other examples are finding single nucleotide polymorphisms that occur in conserved noncoding regions upstream of genes and identifying CpG islands that overlap the S' ends of divergently transcribed genes. The database is available online at http:/ /globin.cse.psu.edu / and http:/ / bio.cse.psu.edu /.
引用
收藏
页码：732 / 741
页数：10
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